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结核性和恶性胸腔积液中白介素-2、白介素-8、肿瘤坏死因子α和干扰素γ的变化
引用本文:张丽君,温学萍,颜志军.结核性和恶性胸腔积液中白介素-2、白介素-8、肿瘤坏死因子α和干扰素γ的变化[J].现代中西医结合杂志,2008,17(12):1789-1791.
作者姓名:张丽君  温学萍  颜志军
作者单位:上海瑞金医院闵行区中心医院,上海,201100
摘    要:目的观察胸腔积液中白介素-2(IL-2)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)和干扰素-γ(IFN-γ)在结核性和恶性胸腔积液中的含量及其对鉴别诊断的价值。方法测定并比较111例结核性、恶性、肺炎性及漏出液4组不同病因胸腔积液患者血清IL-2、IL-8、TNF-α和IFN-γ水平。结果结核性、恶性组患者胸腔积液和血清中的IL-8、TNF-α和IFN-γ水平显著高于漏出液组(P均<0.01);结核性胸腔积液组患者胸液中IL-8、TNF-α和IFN-γ含量明显高于恶性胸腔积液组(P均<0.05);结核性胸腔积液组患者血清中IFN-γ含量明显高于恶性胸腔积液组(P<0.05)。结论胸腔积液中IL-8、TNF-α和IFN-γ联检可能对结核性和恶性胸腔积液之间的鉴别都有较高的临床意义。

关 键 词:胸腔积液  白介素-2  白介素-8  肿瘤坏死因子α  干扰素-γ
文章编号:1008-8849(2008)12-1789-03
修稿时间:2008年1月20日

The changes of Interleukin-2 and interleukin-8 and tumour necrosis ffactor-α and interferon-γ of tuberculous and malignant pleural effusions
zhang Lijun,wen Xueping,Yan Zhijun.The changes of Interleukin-2 and interleukin-8 and tumour necrosis ffactor-α and interferon-γ of tuberculous and malignant pleural effusions[J].Modern Journal of Integrated Chinese Traditional and Western Medicine,2008,17(12):1789-1791.
Authors:zhang Lijun  wen Xueping  Yan Zhijun
Abstract:Objective It is to observe and compare the significance of interleukin-2(IL-2),interleukin-8(IL-8),tumour necrosis factor-α(TNF-α),and interferon-γ(IFN-γ) in pleural effusions for the diagnosis of tuberculous and malignant pleural effusions.Methods The effusion and serum levels of IL-2,IL-8,TNF-α and IFN-γwere measured in 111 patients with pleural effusion.Results The effusion and serum levels of IL-8,TNF-αand INFγ in tuberculous and malignant effusion patients were significantly higher than those pleural transudate patients(P<0.01).The levels of IL-8,TNF-αand IFN-γ in pleural effusion of tuberculous effusion were obviously higher than those with malignant effusion(P<0.05).The serum level of IFN-γ in tuberculosis pleural effusion was obviously higher than those with malignant effusion(P<0.05).Conclusion The determination of IL-8,TNF-α and IFN-γ levels in pleural effusions may be beneficial to identification of tuberculous and malignant effusions.
Keywords:Pleural effusion  interleukin-2  interleukin-8  tumor necrosis factor-α  Interferon-γ
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