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海珠益肝胶囊治疗HBV前C区基因突变患者的疗效观察
引用本文:龚钰清,任泽久,陈悦,李东,朱琳,盛国光.海珠益肝胶囊治疗HBV前C区基因突变患者的疗效观察[J].现代中西医结合杂志,2004,13(17):2265-2266.
作者姓名:龚钰清  任泽久  陈悦  李东  朱琳  盛国光
作者单位:1. 郧阳医学院附属太和医院,湖北,十堰,442000
2. 湖北中医学院,湖北,武汉,430061
基金项目:国家“九五”攻关课题重点研究项目 (96 - 90 6 - 0 8-0 1 )
摘    要:目的 观察海珠益肝胶囊治疗HBV前C区突变慢性乙肝患者的近期疗效。方法观察海珠益肝胶囊治疗 32例HBV突变株患者的疗效 ,并同野生株组做对照 ,比较 2组肝功能、HBV -DNA定量和近期应答率的变化。结果  2组治疗后肝功能复常率、近期应答率及HBV-DNA定量下降程度相近 ,经统计学比较无显著性差异 (P >0 .0 5 )。结论 海珠益肝胶囊对HBV前C区突变株及野生株均有作用 ,2组的近期疗效相似

关 键 词:海珠益肝胶囊  乙型肝炎病毒  基因突变
文章编号:1008-8849(2004)17-2265-02
修稿时间:2004年2月10日

Curative effect observation of Haizhu Yigan capsule on HBV pri-C gene mutation patients
GONG Yu-qing ,REN Ze-jiu ,CHEN Yue ,LI Dong ,ZHU Lin ,SHENG Guo-guang.Curative effect observation of Haizhu Yigan capsule on HBV pri-C gene mutation patients[J].Modern Journal of Integrated Chinese Traditional and Western Medicine,2004,13(17):2265-2266.
Authors:GONG Yu-qing  REN Ze-jiu  CHEN Yue  LI Dong  ZHU Lin  SHENG Guo-guang
Institution:GONG Yu-qing 1,REN Ze-jiu 1,CHEN Yue 1,LI Dong 1,ZHU Lin 1,SHENG Guo-guang 2
Abstract:Objective It is to observe the short-term curative effect of Haizhu Yigan capsule on chronic hepatitis B patients with HBV pre-C gene mutation.Methods The curative effect of Haizhu Yigan capsule on 32 patients with HBV pre-C mutants was observed and compared with the wild type group. The changes of liver function, HBV-DNA content and short-term response rate in the two groups were observed.Results The liver function getting right rate, short-term response rate and HBV-DNA content in the two groups was similar, and there was no obvious difference (P>0.05).Conclusion Haizhu Yigan capsule has effect on both HBV pre-C mutants and wild type. The short-term curative effect of the two groups is similar.
Keywords:Haizhu Yigan capsule  hepatitis B virus  gene mutation
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