消水方联合顺铂胸腔灌注治疗恶性胸腔积液的疗效观察

目的观察消水方联合顺铂胸腔内灌注治疗恶性胸腔积液的疗效。方法将2010年4月—2013年3月中国中医科学院广安门医院南区收治的恶性胸腔积液患者60例随机分为治疗组（30例）和对照组（30例）。两组患者均给予基础治疗，静脉滴注复方苦参注射液15mL／次，1次／d；同时给予胸腔内灌注注射用顺铂40mg／m2，1次／周，2周为1个疗程。治疗组在此基础上给予口服消水方，连用14d，4周后评价疗效。结果胸腔积液缓解情况：治疗组总有效率为76．7％，对照组总有效率为66．7％，两组比较差异无统计学意义；治疗组较对照组在临床症状、生活质量方面明显改善，且差异具有统计学意义（P〈0．05）。结论消水方联合顺铂胸腔灌注治疗恶性胸腔积液可明显改善患者临床症状，提高生活质量，值得临床推广。

Clinical observation of Xiaoshui Decoction combined with cisplatin intrapleural infusion in treatment of malignant pleural effusion

Objective To evaluate the efficacy of Xiaoshui Decoction combined with cisplatin intrapleural infusion in treatment of malignant pleural effusion. Methods Patients （60 cases） with malignant pleural effusion, who came to Southern Branch of Guang＇anmen Hospital, China Academy of Chinese Medical Sciences from April 2010 to March 2013, were randomly divided into treatment （30 cases） and control （30 cases） groups. All patients were given basic treatment： Compound Kushen Injection 15 mL/time, once daily. Cisplatin for injection （40 mg/m2） was poured to the thoracic cavity of the patients once per week for two weeks. The patients in the treatment group were po administered with Xiaoshui Decoction on the basis of control group. And the evaluation was made after 4 weeks. Results The total effective rates for the patients in both the treatment and control groups were 76.7% and 66.7% in pleura1 effusion remission, and there was no significant difference. Compared with the control group, the clinical symptom and quality of life for the patients in the treatment group were improved significantly （P 〈 0.05）. Conclusion Xiaoshui Decoction combines with cisplatin intrapleural infusion in the treatment of malignant pleural effusion could significantly improve the clinical symptoms, quality of life, which is worthy of clinical application.