白芨多糖抗实验性胃溃疡的研究

目的：考察白芨多糖对实验性胃溃疡的影响。方法：采用小鼠无水乙醇致胃溃疡模型和大鼠醋酸致胃溃疡模型，采用试剂盒对大鼠血清中的丙二醛（MDA）和超氧化物歧化酶（SOD）的含量进行测定。结果：白芨多糖（BT01，50，100，200mg·kg^-1）能明显降低无水乙醇致小鼠胃溃疡；白芨多糖（25，50，100mg·kg^-1）降低乙酸致大鼠胃溃疡；降低渍疡大鼠血清中MDA含量，提高SOD含量。结论：白芨多糖具有抗实验性胃溃疡的作用，其抗胃溃疡的机制可能是通过抑制脂质过氧化反应，促进胃黏膜修复。

The Experimental Research on Antiulcer Action of Bletilla Pseudobulb Polysaccharides

Objective： To observe the influence of Common Bletilla Pseudobulb polysaccharides （BTOI） to experimental gastric ulcer. Method： Absolute ethyl alcohol induced - gastric ulcer model of mouse and acetic acid induced - gastric ulcer model of rat were used in this trial, and the amount of malonaldehyde （MDA） and superoxide dismutase （SOD） in rat blood serum was measured with kit. Results： Common Bletilla Pseudobulb polysaccharides（ BT01,50,100,200mg·kg^-1 ）significantly inhibite absolute ethyl alcohol induced- gastric ulcer of mouse; Common Bletilla Pseudobulb polysaccharides （ BT01,25,50,100mg·kg^-1） inhibite acetic acid induced - gastric ulcer of rat, and decrease the amount of MDA, increase the mount of SOD in rat blood serum. Conclusion： Common Bletilla Pseudobulb polysaccharides （BT01） inhibites experimental gastric ulcer, and the mechanism of anti - gastric ulcer action may be in the way of inhibiting lipid overoxidation and faciliating reparation of gastric mucosa.