清热化瘀汤对急性脑出血患者血清hs-CRP、血浆S100β蛋白和NSE的影响

目的:探究清热化瘀汤联合依达拉奉对急性脑出血患者血清超敏C反应蛋白(hs-CRP)、血浆S100β蛋白和神经元特异性烯醇化酶(NSE)的影响。方法:选择2017年5月—2019年5月在我院神经内科就诊符合纳入标准的80例急性脑出血患者,随机分为联合组(40例)和依达拉奉组(40例),两组均给予基础治疗和依达拉奉静脉滴注治疗,联合组则在此基础上加用清热化瘀汤。观察并比较两组的临床疗效、神经功能缺损程度评分(NIHSS)、格拉斯哥昏迷评分(GCS)、hs-CRP、S100β蛋白和NSE水平及脑血肿量。结果:联合组的总有效率为95%(38/40),显著高于依达拉奉组的总有效率75%(30/40)(P<0.05)。治疗后,两组NIHSS评分降低,GCS评分升高,且联合组NIHSS评分明显低于依达拉奉组(P<0.05),GCS评分高于依达拉奉组(P<0.05)。治疗后,两组hs-CRP、S100β蛋白和NSE水平及均脑血肿量均低于治疗前,且联合组hs-CRP、S100β蛋白和NSE水平及脑血肿量明显低于依达拉奉组(P<0.05)。结论:清热化瘀汤联合依达拉奉对急性脑出血患者具有良好的疗效,可显著改善其神经缺损,降低hs-CRP、S100β蛋白和NSE水平及脑血肿量。

Effect of Qingre Huayu Decoction on Serum hs-CRP,Plasma S100β Protein and NSE in Patients with Acute Cerebral Hemorrhage

Objective:To investigate the effects of Qingre Huayu Decoction combined with Edaravone on serum high sensitivity C-reactive protein(hs-CRP),plasma S100βprotein and neuron-specific enolase(NSE)in patients with acute cerebral hemorrhage.Methods:80 patients met the inclusion criteria were randomly divided into the treatment group(n=40)and the control group(n=40).The control group was treated with basic therapy and the therapy of Edaravone intravenous drip;on which basis,the treatment group was also treated with Qingre Huayu Decoction.The curative effects,the scores of NIHSS and GCS,the levels of hs-CRP,S100βprotein and NSE,as well as cerebral hematoma volume were observed and compared in the two groups.Results:The total effective rate was 95%(38/40)in the treatment group,which was significantly higher than 75%(30/40)in the control group(P<0.05).The scores of NIHSS were decreased and the scores of GCS were increased in the two groups after the treatment(P<0.05);of which the improvements in the treatment group were more significant(P<0.05).The levels of hs-CRP,S100βprotein and NSE,as well as the hematoma volume were significantly decreased in the two groups after the treatment(P<0.05);of which the decreases were more significant in the treatment group(P<0.05).Conclusion:Qingre Huayu Decoction combined with Edaravone has good curative effect on acute cerebral hemorrhage,which can significantly improve nerve defects,lower the levels of hs-CRP,S100βprotein and NSE,and reduce the amount of cerebral hematoma.