降逆和胃汤治疗反流性食管炎45例临床研究

目的 探讨降逆和胃汤对反流性食管炎的疗效.方法 75例符合纳入标准的反流性食管炎患者,随机分为两组.治疗组45例,口服降逆和胃汤,每日1剂;对照组30例,口服奥美拉唑20mg,每日1次;疗程为6周.于治疗前后进行临床症状疗效、胃镜下反流性食管炎分级和积分评价.结果 应用降逆和胃汤和奥美拉唑治疗反流性食管炎,均能明显改善患者的临床症状,治疗组痊愈率37.78%,总有效率为84.45%;对照组痊愈率为36.67%,总有效率为83.34%;两组治疗后各症状积分和总积分均明显低于治疗前（P＜0.01）.胃镜下,治疗后两组0级均明显增多,Ⅲ级均为0;治疗组愈合率为48.89%、总有效率为91.11%,对照组愈合率为46.67%、总有效率为93.33%.治疗后组内胃镜疗效比较,差异均有显著性（P＜0.01）.该结果显示,降逆和胃汤在改善反流性食管炎患者的烧心、反酸和胸痛等临床症状、胃镜下食管黏膜炎症以及促进胃镜下食管炎的愈合等方面的疗效与奥美拉唑的疗效相近.结论 降逆和胃汤治疗反流性食管炎具有较好的疗效.

Clinical Study on Treatment of 45 Cases of Reflux Esophagitis with Jiangnihewei Tang

Objective To investigate the therapeutic effect of Jiangnihewei tang on reflux esophagitis (RE). Methods Seventy-five patients with RE were selected according to the diagnostic standard, and randomly divided into the study group (n =45) and the control group (n = 30). Patients in the study group were treated with Jiangnihewei tang orally, one dose per day, and patients in the control group were treated with Omeprazole, 20mg per day. The course of treatment was 6 weeks. Results After therapy, symptoms score given according to severity of main symptoms were significantly lowed in the study group and the control group separately (P < 0.01), and the symptom relief rate was 37.78% and the effective rate was 84.45% in the study group, so 36.67% and 83.34% in the control group. In the study group or the control group, levels of gastric mucosa injury in gastroscope were obviously improved after therapy compared with ones before therapy, respectively (P < 0.01). In gastroscope the healing rate was 48.89% and the effective rate was 91.11% in the study group, so 46.67% and 93.33% in the control group. It indicated that the therapeutic effect of Jiangnihewei tang on RE was close with the therapeutic effect of Omeprazole. Conclusion Jiangnihewei tang was useful in treating reflux esophagitis.