川芎嗪对脑缺血再灌注损伤后细胞间粘附作用的影响

目的 探讨川芎嗪对脑缺血—再灌注损伤后局灶区白细胞与内皮细胞粘附性变化的影响。方法 通过免疫荧光标记技术和显微超高速录像系统观察脑缺血—再灌注及应用川芎嗪后局灶区白细胞粘附性的变化。结果 显示脑缺血—再灌注损伤局灶区微动脉白细胞附壁指数升高，白细胞与内皮细胞间断裂应力降低，粘附力显著增强；应用川芎嗪后附壁指数及粘附力的显著下降，断裂应力增高。结论 川芎嗪可显著减轻脑缺血—再灌注损伤后内皮细胞与白细胞的粘附。

Influence of Ligusticum Chuanxiong Hort (LCH) on Adhesion Force Between Leukocyte and Endothelium after Acute Cerebral Ischemia Reperfusion

Objective To investigate the influence of ligusticum Chuanxiong Hort(LCH)on adhesion force between leukocyte and endothelium in the focus of cerebral ischemia-reperfusion injury Methods Immune fluorescent microscope equipped with image tube camera and high speed recording TV sets was used to study the leukocyte adhesion and the application of LCH in the focus of cerebral ischmia-reperfusion injury.Results The density index of adherent leukocyte was significantly elevated,the fracture stress between leukocyte and endothelium dropped and the adhesion increased in the focus of cerebral ischmia-reperfusion injury.but these were markedly decreased by using LCH.Conclusion Leukocyte adhesion was increased significantly and the application of LCH can decrease the adhesion between leukocyte and endothelium.