| 骨康含药血清对大鼠成骨细胞BMP-2表达的影响 |
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| 引用本文： | 赵可伟,潘昆如,唐菊英.骨康含药血清对大鼠成骨细胞BMP-2表达的影响[J].河南中医,2008,28(7):32-34. |
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| 作者姓名： | 赵可伟 潘昆如 唐菊英 |
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| 作者单位： | 1. 广州中医药大学附属骨伤科医院,广东,广州,510240
2. 中山大学附属二院,广东,广州,510240 |
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| 摘 要： | 目的:通过观察骨康含药血清对成骨细胞BMP-2表达的影响,探讨其治疗骨质疏松症的作用机制。方法:将6只大白兔随机分为3组:正常血清组、骨康含药血清组和雌二醇含药血清组,分别将血清添加入体外分离、培养的成骨细胞,每组8个样本,采用酶联免疫吸附法,检测成骨细胞BMP-2的表达。结果:骨康含药血清组BMP-2含量显著低于空白对照组(P<0.05),骨康含药血清组与雌二醇含药血清组BMP-2的含量无明显差异。结论:在去势状态下,骨康可能通过促进BMP-2的分泌,达到治疗骨质疏松症的目的。
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| 关 键 词： | 骨康 骨形态生成蛋白 成骨细胞 大鼠 |
Effect of Gukang Drug Serum on the Expression of BMP-2 in Osteoblasts of Rats |
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| Zhao Kewei,Pan Kunru,Tang Juying.Effect of Gukang Drug Serum on the Expression of BMP-2 in Osteoblasts of Rats[J].Henan Traditional Chinese Medicine,2008,28(7):32-34. |
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| Authors: | Zhao Kewei Pan Kunru Tang Juying |
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| Abstract: | Objective: Through observing the effect of Gukang drug serum on the expression of BMP-2 in osteoblasts of rats,to probe its mechanism in treating osteoporosis.Methods: Six white rabbits were randomly divided into 3 groups: normal serum group,Gukang drug serum group,estrodiol drug serum group.The serum was respectively added into the osteoblasts isolated and cultured in vitro,8 samples each for group.Enzyme-linked immunosorbent assay was used to detect the expression of BMP-2.Results: The content of BMP-2 in Gukang drug serum group was lower than that of the blank control group(P<0.05).There didn't exit significant difference between the contents of BMP-2 in Gukang drug serum group and estrodiol drug serum group.Conclusion: In the castrated condition,Gukang may reach the purpose of curing osteoporosis by promoting the secretion of BMP-2. |
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| Keywords: | Gukang bone morphogenetic protein osteoblasts rats |
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