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杜仲补肾健骨颗粒联合温针灸治疗肾虚精亏型骨质疏松症临床研究
引用本文:苑成发,闫秀中,房经斌,王金国.杜仲补肾健骨颗粒联合温针灸治疗肾虚精亏型骨质疏松症临床研究[J].河南中医,2017,37(11).
作者姓名:苑成发  闫秀中  房经斌  王金国
作者单位:日照市中医医院,山东日照,276800
基金项目:山东省中医药科技发展计划项目
摘    要:目的:观察杜仲补肾健骨颗粒联合温针灸治疗肾虚精亏型骨质疏松症的临床疗效。方法:本研究选取日照中医医院医院骨伤三科住院治疗的骨质疏松症患者143例,按照随机数字表法分为治疗组72例和对照组71例。所有患者均给予抗骨质疏松症基础治疗,对照组另给予鲑鱼降钙素肌肉注射治疗,治疗组在对照组治疗的基础上加用杜仲补肾健骨颗粒联合温针灸治疗,两组疗程均为16周。观察两组患者中医证候评分、VEGF、TNF-α、TGF-β、PINP及BGP的编号情况。结果:治疗组治疗16周后中医证候评分优于对照组,差异有统计学意义(P0.01);治疗组治疗4周、12周、16周后PINP、BGP、TGF-β水平均优于同期对照组(P0.05);两组治疗4周、12周、16周后VEGF水平与治疗前比较均显著升高(P0.05),且治疗组与同期对照组比较均显著升高(P0.05);治疗组有效率为93%,对照组有效率为51%,治疗组优于对照组(P0.05)。结论:杜仲补肾健骨颗粒联合温针灸治疗肾虚血瘀型原发性骨质疏松症疗效确切,可明显改善中医证候,降低患者血清TNF-α、PINP、TGF-β水平,上调血清VEGF水平。

关 键 词:骨转化生化指标  骨质疏松症  肾虚血瘀证  杜仲补肾健骨汤  温针灸

Clinical Researches on Osteoporosis of Kidney Deficiency and Essence Insufficiency Pattern Treated with Duzhong Kidney-Tonifying and Bone-Strengthening Granules Combined with Warm Acupuncture
YUAN Cheng-fa,YAN Xiu-zhong,FANG Jing-wu,WANG Jin-guo.Clinical Researches on Osteoporosis of Kidney Deficiency and Essence Insufficiency Pattern Treated with Duzhong Kidney-Tonifying and Bone-Strengthening Granules Combined with Warm Acupuncture[J].Henan Traditional Chinese Medicine,2017,37(11).
Authors:YUAN Cheng-fa  YAN Xiu-zhong  FANG Jing-wu  WANG Jin-guo
Abstract:Objective:To observe the clinical effects of Duzhong Kidney-Tonifying and Bone-Strengthening Granules combined with warm acupuncture on osteoporosis of kidney deficiency and essence insufficiency pattern.Methods:Totally 143 patients with osteoporosis treated in the Rizhao Hospital of Chinese Medicine were randomized into treatment group (72 cases) and control group (71 cases).All patients were given basic anti-osteoporosis treatment,while control group were added with intramuscular injection of Salmon Calcitonin Acetate and treatment group were added with Duzhong Kidney-Tonifying and Bone-Strengthening Granules combined with warm acupuncture for the treatment,16 weeks as a treatment course for both groups.The TCM symptom scores,and the changes of the levels of VEGF,TNF-α,TGF-β,PINP and BGP in both groups were observed.Results:After 16 weeks of treatment,the TCM symptom scores in treatment group were superior to those in control group;the difference had statistical significance (P < 0.01).After 4 weeks,12 weeks and 16 weeks of treatment,the levels of PINP,BGP and TGF-βin treatment group were superior to those in control group at the same period of time (P < 0.05);the level of VEGF in both groups increased significantly compared with before treatment (P < 0.05),and the increase in treatment group was remarkable greater than that in control group at the same period of time (P < 0.05).The effective rate was 93 % in treatment group and 51% in control group (P < 0.05).Conclusion:Duzhong Kidney-Tonifying and Bone-Strengthening Granules combined with warm acupuncture has definite therapeutic effects on osteoporosis of kidney deficiency and essence insufficiency pattern,which can significantly improve the TCM symptoms,reduce the levels of TNF-α,PINP and TGF-βand increase the level of VEGF in the serum.
Keywords:biochemical indices  osteoporosis  syndrome of kidney deficiency and essence insufficiency  Duzhong Kidney-Tonifying and Bone-Strengthening Granules  warm acupuncture
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