慢性乙型病毒性肝炎患者中医证型与血小板参数的关系

目的:探讨慢性乙型病毒性肝炎(慢性乙肝)中医证型与血小板检测参数的关系。方法:将162例慢性乙型肝炎住院患者进行中医辨证分型,同时检测其肝功能和血小板计数(platelet,PLT)以及平均血小板体积(Mean platelet volume,MPV)、血小板压积(Platelet aggregation,PCT)、血小板分布宽度(Platelet distribution width,PDW)、大血小板比率(Large platelet ratio,P-LCR),分析其相互关系。结果:各项血小板参数检测中,肝肾阴虚证、脾肾阳虚证与湿热蕴结证比较,差异具有统计学意义(P0.05);瘀血阻络证的PDW、P-LCR与肝郁脾虚证比较,差异具有统计学意义(P0.05);瘀血阻络证的P-LCR与脾肾阳虚证比较,差异具有统计学意义(P0.05)。血小板参数异常率比较,湿热蕴结证除PCT外其他各指标与肝郁脾虚证比较,差异具有统计学意义(P0.05);湿热蕴结证的PDW与P-LCR与脾肾阳虚证比较,差异具有统计学意义(P0.05)。结论:在慢性乙肝患者中,患者中医证型与血小板检测指标有一定的相关性,尤其是与大血小板比率增高关系较密切。

The Relationship Between Traditional Chinese Medical Syndromes and Platelet Parameters of Patients with Chronic Virus Hepatitis B

Objective:To explore the relationship between Chinese medical syndromes and platelet parameters of patients with chronic virus hepatitis B (CHB).Methods:One hundred and sixty-two cases of patients with CHB who were treated in our hospital were divided into different TCM syndromes.Their liver function test,platelet count (PLT),platelet hematocrit (PCT),mean platelet volume (MPV),mean platelet distribution width (PDW) and large platelet ratio (P-LCR) were detected in order to analyze the mutual relationship between them.Results:In the detection of platelet parameters,the difference between yin deficiency of liver and kidney syndrome,spleen-kidney yang deficiency syndrome,and damp heat retention syndrome was statistically significant (P ＜ 0.05).The differences in PDW and P-LCR between syndrome of blood stasis blocking collaterals and liver stagnation and spleen deficiency syndrome were statistically significant (P ＜ 0.05).The difference in P-LCR between syndrome of blood stasis blocking collaterals and spleen-kidney yang deficiency syndrome was statistically significant (P ＜ 0.05).In terms of the abnormal rate of blood platelet parameters,except PCT,the differences in the other indexes between damp heat retention syndrome and liver stagnation and spleen deficiency syndrome were statistically significant (P ＜ 0.05).The differences in PDW and P-LCR between damp heat retention syndrome and spleen-kidney yang deficiency syndrome were statistically significant (P ＜ 0.05).Conclusion:TCM syndromes of CHB patients have some correlation with their platelet parameters,especially with increase of P-LCR.