柴芍六君子汤联合重组人干扰素α-2b治疗慢性乙型病毒性肝炎47例

目的:观察柴芍六君子汤联合重组人干扰素α-2b治疗慢性乙型病毒性肝炎(Chronic Hepatitis B,CHB)的临床疗效。方法:将90例CHB患者随机分为试验组47例和对照组43例。对照组在常规西医治疗的基础上给予重组人干扰素α-2b,试验组在对照组基础上加用柴芍六君子汤。观察两组患者的临床疗效、应答率及不良反应发生率,检测两组患者治疗前后血清丙氨酸氨基转移酶(alanine transaminase,ALT)、天冬氨酸氨基转移酶(aspartateaminotransferase,AST)水平,比较两组患者治疗后中医证候积分。结果:对照组有效率为83.72%,试验组有效率为91.48%,两组患者临床疗效比较,差异具有统计学意义(P0.05)。试验组治疗后中医证候积分高于对照组,差异具有统计学意义(P0.05)。两组患者治疗后血清AST、ALT水平均低于治疗前,且试验组低于对照组,差异具有统计学意义(P0.05)。试验组完全应答率为53.19%,对照组完全应答率为46.51%,两组患者完全应答率比较,差异具有统计学意义(P0.05)。对照组不良反应发生率低于试验组,差异具有统计学意义(P0.05)。结论:柴芍六君子汤可提高重组人干扰素α-2b治疗CHB抗病毒疗效显著,可改善患者生存质量,减少不良反应的发生。

Forty-seven Cases of Chronic Hepatitis B Treated with Bupleurum and Peony Six Gentlemen Decoction in Combination with Recombinant Human Interferon Alpha-2b

Objective:To observe the clinical curative effect of Bupleurum and Peony Six Gentlemen Decoction in combination with recombinant human interferon alpha-2b on chronic hepatitis B(CHB).Methods:Ninety patients with CHB were randomly divided into the experiment group and the control group,with 47 and 43 cases in each group respectively.The ones in the control group were added recombinant human interferon alpha-2b based on routine Western medicine treatment,while the ones in the experiment group were added Bupleurum and Peony Six Gentlemen Decoction based on the treatment of the control group.Then the clinical efficacies,the response rates and adverse reaction rates of the two groups were observed;Their levels of alanine transaminase (ALT) and aspartateaminotransterase(AST) before and after the treatment were detected;And their TCM syndrome scores after the treatment were compared.Results:The effective rate of the control group was 83.72％,while that of the experiment group was 91.48％,and the difference between the two groups was statistically significant (P ＜ 0.05).The score of TCM syndrome in the experiment group was higher than that in the control group,the difference was statistically significant(P ＜ 0.05).The levels of serum AST and ALT in the two groups were lower than those before the treatment,and the experiment group was lower than that of the control group;All the differences were stal istically significant(P ＜ 0.05).The complete response rate of the experiment group was 53.19％,while that of the control group was 46.51％,and the difference was statistically significant (P ＜ 0.05).The incidence of adverse reactions in control group was lower than that in the experiment group,and the difference was statistically significant(P ＜ 0.05).Conclusion:Bupleurum and Peony Six Gentlemeu Decoction can help recombinant human interferon alpha-2b increase its clinical efficacy on CHB,improve the quality of life of patients,and reduce the incidence of adverse reactions.