通脉降脂饮对痰瘀互阻型动脉粥样斑块稳定性的影响

目的:观察通脉降脂饮治疗痰瘀互阻型动脉粥样硬化患者的临床疗效,探讨通脉降脂饮干预动脉粥样硬化斑块稳定性的可能机制。方法:选取2018年1-12月在佛山市禅城区人民医院门诊就诊或健康体检的急性心脑血管事件后2周的患者175例,随机分为对照组86例和观察组89例,对照组口服阿司匹林肠溶片、辛伐他汀分散片治疗,观察组在对照组治疗的基础上加服通脉降脂饮,日1剂,两组疗程均为6个月。观察两组患者临床疗效及相关指标变化情况。结果:对照组有效率为83.72%,观察组有效率为93.26%,两组有效率比较,差异有统计学意义(P<0.05)。两组患者治疗前血清超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、金属基质蛋白酶9(Matrix metalloproteinase 9,MMP-9)、血同型半胱氨酸(homocysteine,Hcy)比较,差异无统计学意义(P>0.05)。治疗后两组血清Hs-CRP、MMP-9、Hcy与治疗前比较,差异有统计学意义(P<0.05);两组急性心脑血管事件后血清Hs-CRP、MMP-9、Hcy与治疗前比较,差异有统计学意义(P<0.05);急性心脑血管事件后血清Hs-CRP、MMP-9、Hcy组间比较,差异有统计学意义(P<0.05)。对照组急性心脑血管事件发生率为23.26%,治疗组急性心脑血管事件发生率为11.24%,两组急性心脑血管事件发生率比较,差异有统计学意义(P<0.05)。两组均未发生死亡、肝肾异常等病例。结论:通脉降脂饮可以降低动脉粥样硬化患者血清Hs-CRP、MMP-9、Hcy,减少急性心脑血管事件的发生。

The Influence of Channel-Unblocking and Fat-Reducing Decoction on the Stability of Atherosclerotic Plaque with Intermingled Phlegm and Blood Stasis Syndrome

Objective:To observe the clinical curative effect of Channel-Unblocking and Fat-Reducing Decoction on atherosclerotic plaque with intermingled phlegm and blood stasis syndrome,and explore its possible mechanism of interfering the stability of atherosclerotic plaque.Methods:A total of 175 patients who were treated for 2 weeks in the outpatient department or for physical examination in Foshan Chancheng District People′s Hospital from January to December 2018 were selected and randomly divided into the control group with 86 cases and the observation group with 89 cases,The control group was treated with Aspirin Enteric-Coated Tablets and Simvastatin Dispersible Tablets.The observation group was additionally treated with Channel-Unblocking and Fat-Reducing Decoction on the basis of the control group,one dose per day.The course of treatment in both groups lasted for 6 months.The clinical efficacies and the changes of related indexes of the two groups were observed.Results:The effective rate was 83.72% in the control group and 93.26% in the observation group.The difference was statistically significant(P<0.05).Before the treatment,the differences in the serum levels of hypersensitive C-reactive protein(hs CRP),Matrix metalloproteinase-9(MMP-9)and homocysteine(Hcy)between the two groups were not statistically significant(P>0.05).However,there were significant differences in hs-CRP,MMP-9 and Hcy between the two groups after treatment and before treatment(P<0.05).There were statistically significant differences in hs-CRP,MMP-9 and Hcy between the two groups after acute cardio cerebrovascular occurrence and before the treatment(P<0.05);there were also statistically significant differences in hs-CRP,MMP-9 and Hcy between the two groups after acute cardio cerebrovascular events(P<0.05).The incidence of acute cardiovascular and cerebrovascular events was 23.26% in the control group and 11.24% in the treatment group.The difference between the two groups was statistically significant(P<0.05).There was no death,liver and kidney abnormality in both groups.Conclusion:Channel-Unblocking and Fat-Reducing Decoction can reduce the serum hs-CRP,MMP-9,Hcy and the occurrence of acute cardiovascular and cerebrovascular events.