益气养阴解毒方联合环磷腺苷葡胺注射液治疗病毒性心肌炎35例

目的:探讨益气养阴解毒方联合环磷腺苷葡胺注射液对病毒性心肌炎患者心功能及外周血清肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、转化生长因子-β1(transforming growth factor-β1,TGF-β1)和干扰素-γ(interferon-γ,IFN-γ)水平的影响。方法:将70例病毒性心肌炎患者按照随机数字法分为对照组和观察组,每组各35例。两组患者均给予常规治疗,对照组在常规治疗的基础上给予环磷腺苷葡胺注射液静脉滴注,观察组在对照组的基础上联合益气养阴解毒方治疗。比较两组患者的临床疗效及治疗前后左室短轴缩短分数(left ventricular shortening fraction,LVFS)、左心室射血分数(left ventricular ejection fraction,LVEF)、心脏指数(cardiac index,CI)、TNF-α、TGF-β1和IFN-γ水平。结果:观察组有效率为88.57%,对照组有效率为68.57%,两组患者有效率比较,差异有统计学意义(P<0.05)。两组患者治疗后LVEF、LVFS高于本组治疗前,且观察组高于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后TGF-β1、TNF-α水平低于治疗前比较,IFN-γ高于治疗前,且观察组TGF-β1、TNF-α低于对照组,IFN-γ高于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:益气养阴解毒方联合环磷腺苷葡胺注射液治疗病毒性心肌炎疗效更显著,可减轻机体的炎症反应,恢复患者心功能。

Thirty-Five Cases of Viral Myocarditis Treated with Decoction for Nourishing Qi and Yin and Removing Toxicity in Combination with Meglumine Cyclophosphate Injectio

Objective:To explore the influence of Decoction for Nourishing Qi and Yin and Removing Toxicity in combination with Meglumine Cyclophosphate Injection on cardiac function and the levels of tumor necrosis factor-α(TNF-α),transforming growth factor-β1(TGF-β1)and interferon-γ(IFN-γ)in peripheral serum of patients with viral myocarditis.Methods:A total of 70 patients with viral myocarditis were randomly divided into the control group and the observation group,with 35 cases in each group.The patients in the two groups were first given conventional treatment,then the control group was additionally given Meglumine Cyclophosphate Injection for intravenous drip,while the observation group was additionally given Decoction for Nourishing Qi and Yin and Removing Toxicity on the basis of the control group.The clinical effects and the levels of left ventricular shortening fraction(LVFS),left ventricular ejection fraction(LVEF),cardiac index(CI),TNF-α,TGF-β1 and IFN-γbefore and after the treatment were compared between the two groups.Results:The effective rate was 88.57%in the observation group and 68.57%in the control group,and the difference was statistically significant(P<0.05).After the treatment,LVEF and LVFS of the two groups were higher than those of the same group,and the observation group was higher than the control group,and all the differences were statistically significant(P<0.05).After the treatment,the levels of TGF-β1 and TNF-αin the two groups were lower than those before the treatment,and IFN-γwas higher than that before the treatment.The levels of TGF-β1 and TNF-αin the observation group were lower than those in the control group,and IFN-γwas higher than that in the control group,and all the differences were statistically significant(P<0.05).Conclusion:Decoction for Nourishing Qi and Yin and Removing Toxicity in combination with Meglumine Cyclophosphate Injection has a remarkable clinical curative effect on viral myocarditis,can reduce the inflammatory reaction of the body and restore the heart function of the patients.