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| 大花罗布麻叶总黄酮对缺氧小鼠脑组织保护作用 | |
| 引用本文： | 孙江兵,金星,周军.大花罗布麻叶总黄酮对缺氧小鼠脑组织保护作用[J].亚太传统医药,2011,7(10):57-59. |
| 作者姓名： | 孙江兵 金星 周军 |
| 作者单位： | 1. 解放军第23医院,新疆乌鲁木齐,830000 2. 乌鲁木齐市头屯河区中心医院,新疆乌鲁木齐,830023 3. 兰州军区乌鲁木齐总医院,新疆乌鲁木齐,830002 |
| 摘 要： | 目的:探讨大花罗布麻叶总黄酮对缺氧小鼠脑组织保护作用。方法:灌胃给予高、低剂量的大花罗布麻叶总黄酮(250、100mg/kg),模拟高原海拔5000m缺氧环境建立小鼠缺氧模型,测定小鼠脑组织含水量和乳酸含量,以及脑组织中超氧物歧化酶(SOD)、脂质过氧化物丙二醛(MDA)和乳酸脱氢酶(LDH)活性,观察大花罗布麻叶总黄酮对缺氧小鼠脑保护作用。结果:与缺氧模型组相比,大花罗布麻叶总黄酮能明显降低缺氧状态下小鼠脑组织的含水量和乳酸含量以及MDA的活性,明显增加小鼠脑组织中SOD和LDH活性。结论:大花罗布麻叶总黄酮对缺氧小鼠脑组织具有保护作用,其机制可能与其提高缺氧状态下乳酸脱氢酶(LDH)活性,减轻乳酸在脑组织中的积累,抑制脂质过氧化物MDA以及增强脑组织中抗氧化酶SOD活性有关。 |
| 关 键 词： | 大花罗布麻叶总黄酮 抗缺氧 小鼠 |
The Protective Effect of Total Flavonoids of Apoacynum Venetum Leaves in Brain of Anoxic Mice |
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| Sun Jiang Bing,Jin Xing,Zhou Jun.The Protective Effect of Total Flavonoids of Apoacynum Venetum Leaves in Brain of Anoxic Mice[J].Asia-Pacific Traditional Medicine,2011,7(10):57-59. | |
| Authors: | Sun Jiang Bing Jin Xing Zhou Jun |
| Institution: | Sun Jiang Bing1,Jin Xing2,Zhou Jun3(1.Department Clinical Laboratory,Hospital 23 of PLA,Urumqi 830000,China,2.Department of Pharmacy,Urumqi TouTunHe Hospital,Urumqi 830023,3.Department of Pharmacy,Urumqi General Hospital of PLA,Urumqi 830002,China) |
| Abstract: | Objective:To study the anti-hypoxia effect of total flavonoids of Apoacynum venetum Leaves on mice and its mechanism. Methods:According to the purpose of the experiment,the mechanisms of anti-hypoxia effect were investigated by establishing the anoxic model under low pressure conditions similar to the plateau environment of 5000 m altitude.The content of water and lactic acid in brain tissue,SOD activity,MDA activity and LDH activity were measured. Results:Total flavonoids obviously decreased the content of... |
| Keywords: | Total Flavonoids of Apoacynum Venetum Leaves Anti-hypoxia Mice |
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