More insights into the pharmacological effects of artemisinin |
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| Authors: | Abdelmajid Zyad Abdeslam Jaafari Moulay Ali Oukerrou Hassan Ait Mouse |
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| Institution: | 1. Laboratory of Biological Engineering, Team of Natural Substances and Cellular and Molecular Immuno‐pharmacology, Immuno‐biology of Cancer Cells, Sultan Moulay Slimane University, Faculty of Science and Technology, MoroccoAbdelmajid Zyad and Mounir Tilaoui contributed equally to this work;2. Laboratory of Biological Engineering, Team of Natural Substances and Cellular and Molecular Immuno‐pharmacology, Immuno‐biology of Cancer Cells, Sultan Moulay Slimane University, Faculty of Science and Technology, Morocco |
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| Abstract: | Artemisinin is one of the most widely prescribed drugs against malaria and has recently received increased attention because of its other potential biological effects. The aim of this review is to summarize recent discoveries of the pharmaceutical effects of artemisinin in basic science along with its mechanistic action, as well as the intriguing results of recent clinical studies, with a focus on its antitumor activity. Scientific evidence indicates that artemisinin exerts its biological activity by generating reactive oxygen species that damage the DNA, mitochondrial depolarization, and cell death. In the present article review, scientific evidence suggests that artemisinin is a potential therapeutic agent for various diseases. Thus, this review is expected to encourage interested scientists to conduct further preclinical and clinical studies to evaluate these biological activities. |
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| Keywords: | antitumor activity artemisinin pharmacological activities |
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