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Bioassay-guided isolation and identification of antifungal compounds from ginger
Authors:Ficker C  Smith M L  Akpagana K  Gbeassor M  Zhang J  Durst T  Assabgui R  Arnason J T
Institution:Ottawa-Carleton Institutes of Biology and Chemistry, Carleton University and University of Ottawa, Ottawa ON, Canada.
Abstract:A bioassay-guided isolation of antifungal compounds from an African land race of ginger, Zingiber officinale Roscoe, led to the identification of 6], 8] and 10]-gingerols and 6]-gingerdiol as the main antifungal principles. The compounds were active against 13 human pathogens at concentrations of <1 mg/mL. The gingerol content of the African land race was at least 3 x higher than that of typical commercial cultivars of ginger. Therefore, ginger extracts standardized on the basis of the identified compounds, could be considered as antifungal agents for practical therapy.
Keywords:African ginger  human pathogenic fungi  antifungal  gingerols  gingerdiol
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