Bioassay-guided isolation and identification of antifungal compounds from ginger |
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Authors: | Ficker C Smith M L Akpagana K Gbeassor M Zhang J Durst T Assabgui R Arnason J T |
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Institution: | Ottawa-Carleton Institutes of Biology and Chemistry, Carleton University and University of Ottawa, Ottawa ON, Canada. |
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Abstract: | A bioassay-guided isolation of antifungal compounds from an African land race of ginger, Zingiber officinale Roscoe, led to the identification of 6], 8] and 10]-gingerols and 6]-gingerdiol as the main antifungal principles. The compounds were active against 13 human pathogens at concentrations of <1 mg/mL. The gingerol content of the African land race was at least 3 x higher than that of typical commercial cultivars of ginger. Therefore, ginger extracts standardized on the basis of the identified compounds, could be considered as antifungal agents for practical therapy. |
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Keywords: | African ginger human pathogenic fungi antifungal gingerols gingerdiol |
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