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不同酯化度果胶对苦豆子总碱水凝胶骨架片体外释放的影响
引用本文:赵文昌,邓虹珠,宋丽军,黄永恒,黄德浩,姚晖.不同酯化度果胶对苦豆子总碱水凝胶骨架片体外释放的影响[J].中国中药杂志,2008,33(19):2188-2192.
作者姓名:赵文昌  邓虹珠  宋丽军  黄永恒  黄德浩  姚晖
作者单位:南方医科大学,中医药学院,广东,广州,510515
基金项目:广州市科技局科技攻关项目 
摘    要:目的:制备苦豆子总碱水凝胶骨架结肠定位释放片,研究不同酯化度果胶对其释放行为的影响。方法:采用湿法制粒压片法制备不同酯化度果胶骨架片,分别考察其在模拟胃液、肠液中6 h释放情况,在此基础上采用Kollicoat MAE 30DP包衣,分析其在模拟胃液、肠液、盲肠液介质中的释放行为。结果:不同酯化度果胶能够明显影响其在模拟胃液、肠液中的释放。采用Kollicoat MAE 30DP包衣的低酯果胶配方E能够使苦豆子总碱中槐定碱结肠释放,近似零级释放模型,属骨架溶蚀释药机制。结论:肠溶包衣的低酯果胶骨架片靶向性强,能够使苦豆子总碱定位释放,从而提高疗效。

关 键 词:低酯果胶  高酯果胶  苦豆子总碱  槐定碱  结肠定位释放
收稿时间:5/4/2008 12:00:00 AM

Effect of pectins of different degree of esterification on in-vitro sophoridine release of hydrophilic matrix tablets containingtotal alkaloids of Sophora alopecuroides
ZHAO Wen-chang; DENG Hong-zhu; SONG Li-jun; HUANG Yong-heng; HUANG,De-hao; YAN Hui.Effect of pectins of different degree of esterification on in-vitro sophoridine release of hydrophilic matrix tablets containingtotal alkaloids of Sophora alopecuroides[J].China Journal of Chinese Materia Medica,2008,33(19):2188-2192.
Authors:ZHAO Wen-chang; DENG Hong-zhu; SONG Li-jun; HUANG Yong-heng; HUANG  De-hao; YAN Hui
Abstract:Objevtive: To prepare colon-targetting tablets of total alkaloids of Sophora alopecuroides and evaluate the effect of pectins of different degree of esterification (DE) on sophoridine release profiles in-vitro. Method: Wet granulation technique was employed to prepare petin-based matrix tablets,then tablets were coated the optimal formulation with Kollicoat MAE 30 DP based on the optimal formulation and analysed their release. Result: Coated formulation E could target total alkaloids of S. alopecuroides to colon and various DE of pectin exerted different effects on sophoridine release. The release of low DE pectin-based matrix tablets coating with Kollicoat MAE 30 DP approximatedly fitted zere-order eqution, which was erosion depended-. Conclusion: Low DE pectin-based matrix tablet coating with Kollicoat MAE 30 DP can deliver sophoridine to colon, hence improve the effectiveness of sophoridine.
Keywords:low DE pectin  high DE pectin  total alkaloids of Sophora alopecuroides  sophoridine  colon-specific drug delivery
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