| 茅莓总皂苷对大鼠局灶性脑缺血的保护作用 |
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| 引用本文： | 王继生,邱宗荫,夏永鹏,李惠芝,任凌燕,张莉.茅莓总皂苷对大鼠局灶性脑缺血的保护作用[J].中国中药杂志,2006,31(2):138-141. |
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| 作者姓名： | 王继生 邱宗荫 夏永鹏 李惠芝 任凌燕 张莉 |
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| 作者单位： | 重庆医科大学,药学系,重庆,400016 |
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| 摘 要： | 目的:研究茅莓总皂苷(TGRP)对局灶性脑缺血的保护作用。方法:采用大脑中动脉阻塞(MACO)法制备大鼠局灶性脑缺血模型;脑梗死区重量用TTC染色法测定,超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)及细胞凋亡均采用测试药盒测定。结果:TGRP 10,20 mg.kg-1可改善大鼠异常神经症状,使MACO大鼠的SOD,GSH-Px活力提高,MDA生成减少,减少脑皮层细胞凋亡数。结论:TGRP对脑梗死有保护作用,其作用机制可能与抗自由基、抑制细胞凋亡有关。
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| 关 键 词： | 茅莓总皂苷 大脑中动脉阻塞 超氧化物歧化酶 丙二醛 谷胱甘肽过氧化物酶 凋亡 |
| 文章编号： | 1001-5302（2006）02-0138-04 |
| 收稿时间： | 5/8/2005 12:00:00 AM |
| 修稿时间： | 2005-05-08 |
The preotective effects of total glycosides Rubus parviflolius on cerebral ischemica in rat |
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| WANG Ji-sheng;QIU Zong-yin;XIA Yong-peng;LI Hui-zhi;REN Ling-yan;ZHANG Li.The preotective effects of total glycosides Rubus parviflolius on cerebral ischemica in rat[J].China Journal of Chinese Materia Medica,2006,31(2):138-141. |
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| Authors: | WANG Ji-sheng;QIU Zong-yin;XIA Yong-peng;LI Hui-zhi;REN Ling-yan;ZHANG Li |
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| Abstract: | Objective: To observe the protective effects of total glycosides Rubus parviflolius(TGRP) on local cerebral ischemic.Method: The local cerebral ischemia in rat was made by middle cerebral artery occlusion(MACO).The infraction weight was determined by TTC stain. SOD,MDA,GSH and apoptotis were determined with different method respectively.Result: TGRP 20,10 mg·kg~(-1)ig markedly improved the abnormal nervous symptoms,incredsed the SOD,GSH activity and reduced contentes of MDA in brain of MACO rat,TGRP 20 mg·kg~(-1) ig significantly decreased the numbers of apoptotic cells in ischemic cortex.Conclusion: TGRP has protective effects against cerebral infrction,and its mechanism may be related to anti-apoptotis and free radical. |
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| Keywords: | total glycosides Rubus parviflolius MACO SOD MDA GSH-pX apoptotis |
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