复方丹参滴丸治疗痰瘀型高脂血症的临床研究

目的：探讨复方丹参滴丸治疗痰瘀型高脂血症的临床疗效。方法：将痰瘀型高脂血症患者81例随机分为2组,治疗组(40例)采用复方丹参滴丸治疗,对照组(41例)采用辛伐他汀治疗,观察治疗后外周血血脂水平和ALT,r-GT,IL-8,MDA及SOD水平的变化。结果：2组治疗后TC,TG,LDL-C均明显下降(P<0.01,P<0.05),治疗组经复方丹参滴丸治疗后,ApoA水平和SOD活性较前明显升高(P<0.05,P<0.01),ALT,r-GT,IL-8和MDA水平明显下降(P<0.01,P<0.05)；对照组经辛伐他汀治疗后,ALT,r-GT,IL-8,MDA及SOD水平无明显变化;2组治疗后的ALT,r-GT水平及SOD活性相比较差异显著(P<0.01,P<0.05)。结论：复方丹参滴丸的降脂作用与其化痰消瘀作用有关,其在降脂的过程中保护肝功能的作用可能与其减轻脂质过氧化程度和炎症因子水平有关,进一步研究复方丹参滴丸痰瘀分消作用在脂质代谢中的机制具有重要意义。

Effection of compositie salviae dropping pill on hyperlipemia patients with phlegm and blood stasis syndrome

Objective: To explore the effect of compositie salviae dropping pill (CSDP) on hyperlipemia patients with phlegm and blood stasis syndrome. Method: Hyperlipemia patients were divided randomly into two groups. One group of 40 patients were treated by CSDP, another group of 41 patients were treated by simvastatin. The TC, TG, HDL-C, LDL-C, ApoA and ApoB levels, ALT, r-GT, IL-6, MDA level and SOD activity were determined before and after being treated. Result: After 3 months treatment, the TC, TG and LDL-C levels were obviously decreased in two groups (P<0.01,P<0.05), there is no significant difference between the effective rate of two g roups. The ALT, r-GT, IL-8 and MDA levels of treatment group were obviously decreased (P<0.01,P<0.05), while the ApoA level and SOD activity increased obviously in those patients (P<0.05,P<0.01, respectively). However, the ALT, r-GT, IL-6, MDA, HDL-C, ApoA level and SOD activity had no significant difference after treatment in control group. Conclusion: Our study suggest that CSDP have the function of falling serum lipid level without damaging liver function, its function of protecting liver function might related to its function of improving of anti-oxidation and decreasing of inflammation, the mechanism of CSDP disparting and removing phlem and blood stasis in the processes lipid metabolism need to be studied further.