| 斑马鱼在药物筛选中的应用 |
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| 引用本文： | 陈志亮.斑马鱼在药物筛选中的应用[J].中国中药杂志,2015,40(7):1235-1239. |
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| 作者姓名： | 陈志亮 |
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| 作者单位： | 漳州片仔癀药业股份有限公司,福建漳州,363000 |
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| 摘 要： | 与其他模式动物相比,斑马鱼在药物的活性成分筛选方面具有独特的优势,近年来在药物研究开发中受到越来越多的重视.该文着重就斑马鱼在中药有效部位研究、中药单体筛选、天然产物和药物“老药新用”的应用前景以及药物的早期毒理评估等方面的最新研究进展进行了综述,以期为广大中药研究开发人员在中药新药研发方面提供借鉴参考.
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| 关 键 词： | 斑马鱼 药物活性成分筛选 高通量筛选 毒理评估 |
| 收稿时间： | 2014/9/12 0:00:00 |
Application of zebrafish in drug screens for active ingredients |
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| CHEN Zhi-liang.Application of zebrafish in drug screens for active ingredients[J].China Journal of Chinese Materia Medica,2015,40(7):1235-1239. |
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| Authors: | CHEN Zhi-liang |
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| Institution: | Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd., Zhangzhou 363000, China |
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| Abstract: | Zebrafish has unique advantages over other animal models in the aspect of drug screens for active ingredients and gains more and more attentions in drug research and development recently. Thus, this article reviews the recent advance of zebrafish-based drug screens in Chinese traditional medicine (TCM) effective part research, monomer drug screening, activity evaluation of natural products, discovery of new uses for old drugs, and toxicity assessment in early-phase drug discovery. |
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| Keywords: | zebrafish drug screens for active ingredients high-throughput screening toxicity assessment |
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