中风康对局灶性脑缺血大鼠脑组织胰岛素样生长因子-1含量的影响

目的:探讨中风康对局灶性脑缺血大鼠脑组织胰岛素样生长因子-1(IGF-1)含量的影响。方法:采用线栓法复制局灶性脑缺血大鼠模型,以步长脑心通为对照,于脑缺血6,12,24,48 h动态观察中风康对局灶性脑缺血大鼠脑梗死体积和脑组织IGF-1含量的影响。结果:与假手术组比较,局灶性脑缺血6 h,模型组脑组织IGF-1含量开始增加,至24 h达到高峰(P<0.01);与同时点模型组比较,各治疗组脑组织IGF-1含量均有不同程度升高,以高剂量组升高最为显著(P<0.05或P<0.01);与同时点模型组比较,各治疗组梗死灶体积亦有不同程度的降低(P<0.05或P<0.01)。结论:中风康可升高脑梗死大鼠脑组织IGF-1含量,减少脑梗死体积,有效减轻局灶性脑梗死引起的缺血性损伤。

Effect of Zhongfengkang on the content of insulin-like growth factor-1 in brain of the rats with focal cerebral ischemia

Objective: To observe the effect of Zhongfengkang on the content of insulin-like growth factor-1(IGF-1) in brain of focal cerebral ischemia rats.Method: The model of focal cerebral ischemia was made by thread-blocking method.In comparison with the curative effect of buchangnaoxintong,the action of Zhongfengkang on infarct volume and the content of IGF-1 in brain of focal cerebral ischemia rats were observed in 6,12,24 h and 48 h after cerebral ischemia.Result: As compared with sham operation group,the content of IGF-1 in brain of model group was gradually increased from 6th hour after cerebral ischemia,reaching to the maximal level at 24th hour after the onset of cerebral ischemia(P<0.01).In comparison with the values in model group at the corresponding time points,the content of IGF-1 in brain of each treatment groups was increased in different extent with a maximal enhancement in the group treated by the high dose of Zhongfengkang(P<0.05 or P<0.01);while the infarct volume of each treatment groups were decreased significantly(P<0.05 or P<0.01).Conclusion: Zhongfengkang could effectively protect the cerebral tissue from injury of focal cerebral ischemia in the rats through increasing the cerebral content of IGF-1 and reducing infarct volume.