首页 | 本学科首页   官方微博 | 高级检索  
检索        

树枝状聚合物PAMAM包覆葛根素脂质体角膜渗透性研究
引用本文:刘毅,孙考祥,姚文军,梁娜,慕宏杰,梁荣才,姚晨.树枝状聚合物PAMAM包覆葛根素脂质体角膜渗透性研究[J].中国中药杂志,2010,35(1):30-34.
作者姓名:刘毅  孙考祥  姚文军  梁娜  慕宏杰  梁荣才  姚晨
作者单位:烟台大学,药学院药剂教研室,山东,烟台,264005
基金项目:国家自然科学基金项目(30873447)
摘    要:目的:研究树枝状聚合物PAMAM包覆葛根素(puerarin,PUE)脂质体的角膜渗透特性。方法:制备PAMAM G2和PAMAM G3包覆的葛根素脂质体,以葛根素水溶液和未包覆葛根素脂质体为对照,进行兔离体角膜渗透试验,同时考察包覆脂质体中,不同的摩尔投料比(PAMAM磷/脂=0.1%,0.5%,1.0%,2.0%),PAMAM对角膜渗透性的影响,计算渗透参数。结果:PAMAM磷/脂摩尔比为1.0%(PAMAM G2)和0.5%(PAMAM G3)的包覆脂质体的Papp(表观渗透系数),Jss(稳态流量)均明显高于葛根素水溶液和未包覆脂质体(P0.01),且PAMAM磷/脂摩尔比为1.0%(PAMAM G2)和0.5%(PAMAMG3)包覆脂质体的促角膜渗透性高于其他比例包覆的脂质体(P0.01)。结论:PAMAM包覆葛根素脂质体可以显著改善葛根素在兔眼部的角膜渗透性,作为眼用载体有希望增加药物的眼部吸收和生物利用度。

关 键 词:PAMAM  树枝状聚合物  葛根素  包覆脂质体  角膜渗透性
收稿时间:2009/10/2 0:00:00

Corneal penetration of PAMAM dendrimers-coated puerarin liposomes
LIU Yi,SUN Kaoxiang,YAO Wenjun,LIANG N,MU Hongjie,LIANG Rongcai and YAO Chen.Corneal penetration of PAMAM dendrimers-coated puerarin liposomes[J].China Journal of Chinese Materia Medica,2010,35(1):30-34.
Authors:LIU Yi  SUN Kaoxiang  YAO Wenjun  LIANG N  MU Hongjie  LIANG Rongcai and YAO Chen
Institution:School of Pharmacy, Yantai University, Yantai 264005, China;School of Pharmacy, Yantai University, Yantai 264005, China;School of Pharmacy, Yantai University, Yantai 264005, China;School of Pharmacy, Yantai University, Yantai 264005, China;School of Pharmacy, Yantai University, Yantai 264005, China;School of Pharmacy, Yantai University, Yantai 264005, China;School of Pharmacy, Yantai University, Yantai 264005, China
Abstract:Objective: To study the corneal penetration of PAMAM dendrimers-coated puerarin liposomes in rabbits.Method: Evaluated PAMAM(G2,G3)dendrimers-coated puerarin liposomes were prepared and the in vitro transcorneal penetration were compared to puerarin drop solution and uncoated liposomes.The effect of different proportion of PAMAM to phospholipids in formulation on corneal penetration and the penetration parameters were investigated.Result: The steady state fluxes and permeability coefficients of puerarin by ...
Keywords:PAMAM  dendrimer  puerarin  coated liposomes  transcorneal penetration
本文献已被 CNKI 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号