| 补肾强骨胶囊抗骨质疏松药效学的研究 |
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| 引用本文： | 张幸国,赵青威,戴诗文,王绪平,张伟敏.补肾强骨胶囊抗骨质疏松药效学的研究[J].中国中药杂志,2001,26(9):625-627. |
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| 作者姓名： | 张幸国 赵青威 戴诗文 王绪平 张伟敏 |
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| 作者单位： | 1. 浙江大学医学院附属第一医院
2. 浙江中医药研究院 |
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| 摘 要： | 目的 :研究补肾强骨胶囊的抗骨质疏松作用。方法 :利用空白和阳性对照 ,观察补肾强骨胶囊的药理作用 ,并对数据进行生物学统计。结果 :补肾强骨胶囊 ,可使“肾虚”模型小鼠的睾丸重指数及子宫重指数明显增加 ,可提高去势大鼠的股骨密度 ,能减少维甲酸性骨质疏松模型大鼠股骨骨折数 ,显著增加股骨重量 ,提高血钙浓度 ,还具有镇痛、抗炎作用。结论 :补肾强骨胶囊有良好的抗骨质疏松作用 ,为临床疗效提供了实验依据。
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| 关 键 词： | 补肾强骨胶囊 骨质疏松 骨密度 骨折 |
| 文章编号： | 1001-5302(2001)09-0625-03 |
| 收稿时间： | 2/5/2001 12:00:00 AM |
| 修稿时间： | 2001年2月5日 |
Study of the Antiosteoporosis Effects of Bushenqianggu Capsule |
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| Zhang Xin guo ;Zhao Qing wei ;Dai Shi wen ;Wang Xu ping ;Zhang Wei min.Study of the Antiosteoporosis Effects of Bushenqianggu Capsule[J].China Journal of Chinese Materia Medica,2001,26(9):625-627. |
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| Authors: | Zhang Xin guo ;Zhao Qing wei ;Dai Shi wen ;Wang Xu ping ;Zhang Wei min |
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| Institution: | First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310003, Zhejiang, China. |
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| Abstract: | Objective:To study the antiosteoporosis effects of Bushenqianggu capsule. Method: Observing the pharmacological effects of Bushenqianggu capsule with blank and positive control, and then analyzing the data with biological statistics. Result: The testis and uterus weight index of "the kidney assessed" model mice, weight of thighbone and blood concentration of Ca2+ increased significantly. Meanwhile, the thighbone mass density of castrated rats was improved and the incidence of the thighbone fracture in the osteoporosis model rats induced by retinoic acid was reduced. Besides, it had analgesia and anti inflammatory effects. Conclusion: Bushenqianggu capsule has a good effect on osteoporosis, which provides evidence for clinical use. |
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| Keywords: | Bushenqianggu capsule osteoporosis bone mass density fracture |
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