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| 基于组分层次的中药多元释药系统评价体系的构建 | |
| 引用本文： | 郁丹红,刘丹,贾晓斌,孙娥,张振海,萧伟.基于组分层次的中药多元释药系统评价体系的构建[J].中国中药杂志,2012,37(17):2667-2671. |
| 作者姓名： | 郁丹红 刘丹 贾晓斌 孙娥 张振海 萧伟 |
| 作者单位： | 1. 江苏省中医药研究院 国家中医药管理中药释药系统重点研究室,江苏 南京 210028;南京中医药大学,江苏 南京 210028 2. 江苏省中医药研究院 国家中医药管理中药释药系统重点研究室,江苏 南京,210028 3. 江苏康缘药业股份有限公司 中药制药过程新技术国家重点实验室,江苏 连云港,222001 |
| 基金项目： | 江苏省中医药领军人才项目(2006);江苏省中医药科技项目(LZ09061);中药制药过程新技术国家重点实验室开放基金(SKL2010Z0303) |
| 摘 要： | 中药(复方)是多组分的复杂体系,中药制剂的评价体系研究必然要围绕中药组分,考虑组分中多成分、多环节、多靶点的整体作用特点.该文将立足于“中医整体观念”,以方药物质基础组分为前提,结合中药制剂评价体系的发展现状,重点从体外释药特性、体内生物利用度、PK-PD 3个方面构建中药多元释药系统的评价体系；同时尝试提出中药组分程序释放的新思路,以期为复杂的中药(复方)给药系统的深入发展提供参考. |
| 关 键 词： | 中药组分 中药多元释药系统 生物利用度 评价体系 程序释放 |
| 收稿时间： | 2012/3/28 0:00:00 |
Construction of evaluation systems for traditional Chinese medicine multiple drug delivery system on basis of component level |
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| YU Dan-hong,LIU Dan,JIA Xiao-bin,SUN E,ZHANG Zhen-hai and XIAO Wei.Construction of evaluation systems for traditional Chinese medicine multiple drug delivery system on basis of component level[J].China Journal of Chinese Materia Medica,2012,37(17):2667-2671. | |
| Authors: | YU Dan-hong LIU Dan JIA Xiao-bin SUN E ZHANG Zhen-hai and XIAO Wei |
| Institution: | Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Nanjing University of Chinese Medicine, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Nanjing University of Chinese Medicine, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Jiangsu Kanion Pharmaceut Co., Ltd., Lianyungang 222001, China |
| Abstract: | Traditional Chinese medicine (TCM) is a multi-component complex system and its research must consider its components characteristics of multi-component, multi-target and multi-effect. According to the whole concept of Chinese medicine, also combining with the status quo of Chinese drugs pharmaceutics and setting the material basis component as the premise, this study will develope TCM multiple drug delivery evaluation system, respectively from three aspects, namely in vitro release, in vivo bioavailability and PK-PD. At the same time, we will try to offer the new thoughts of the programly release, so as to provide new strategies and methods for the development of modern Chinese drug delivery systems. |
| Keywords: | component of traditional Chinese medicine TCM multiple drug delivery system bioavailability evaluation systems programly release |
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