小儿腹泻外敷散对胃肠动力学的影响

该文主要探讨小儿腹泻外敷散对胃肠动力学的影响。首先采用炭末推进法观察小儿腹泻外敷散对正常和虚泻小鼠肠运动的影响,结果表明其对正常小鼠组的炭末推进并无显著性的抑制作用,对番泻叶致虚泻小鼠的炭末推进有显著性的抑制作用;然后以腹泻指数为指标,观察其对虚泻小鼠腹泻的影响,结果表明其对番泻叶所致的虚泻小鼠具有良好的抗腹泻作用;随后的大鼠离体肠平滑肌测试结果表明小儿腹泻外敷散可竞争性拮抗由乙酰胆碱、氯化钡引起的胃肠痉挛,且与阿托品具有一定协同作用;最后采用放射免疫法测定敷药前后大鼠小肠中P物质(SP)、血管活性肠肽(VIP)含量的变化,结果表明敷药后大鼠小肠中的SP降低,VIP含量降低,可抑制小肠运动。在体和离体实验均表明,小儿腹泻外敷散为一种良好的胃肠动力型外敷中药,对脾虚泄泻所致腹泻小鼠有抗腹泻作用。

Effect of Xiaoer Fuxie Waifu powder on gastrointestinal dynamics

To explore the effect of Xiaoer Fuxie Waifu powder on gastrointestinal dynamics. In the study, the charcoal powder propelling test was used to observe the effect Xiaoer Fuxie Waifu powder on the intestinal motility of normal mice and deficient diarrheal mice. The results showed that Xiaoer Fuxie Waifu powder had no obvious inhibitory effect on the powder propelling in normal mice, but a remarkable inhibitory effect on deficient diarrheal mice. Afterwards, diarrhea index was used to observe the effect on deficient diarrheal mice. The results showed a good anti-diarrhea effect in deficient diarrheal mice induced by folium sennae. According to the subsequent isolated intestines smooth muscle test, Xiaoer Fuxie Waifu powder showed a competitive antagonism on muscular tension caused by acetyl choline and barium chloride, as well as a certain synergistic action with atropine. Finally, the method of radio-immunity was used to determine the contents of SP and VIP in small intestine of mice, showing that SP and VIP in small intestine of mice were decreased and the motility of intestine was inhibited. In conclusion, both in vitro and in vivo experiments indicate that Xiaoer Fuxie Waifu powder is a good traditional Chinese gastrointestinal dynamic medicine for external application, with an anti-diarrhea effect on diarrhea mice induced by spleen deficiency and diarrhea.