| 近红外光谱法快速测定消渴丸药粉中葛根素含量 |
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| 引用本文： | 苏碧茹,叶彬,耿春贤,石猛,吴长海.近红外光谱法快速测定消渴丸药粉中葛根素含量[J].中国中药杂志,2011,36(6):672-675. |
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| 作者姓名： | 苏碧茹 叶彬 耿春贤 石猛 吴长海 |
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| 作者单位： | 广州中一药业有限公司,广州,510530 |
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| 基金项目： | 国家"重大新药创制"科技重大专项(2009ZX09308-003) |
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| 摘 要： | 目的:采用近红外光谱法对消渴丸药粉中葛根素含量进行快速测定.方法:以HPLC分析值作为参照,采用近红外漫反射光谱技术采集消渴丸药粉的近红外光谱,结合偏最小二乘法建立葛根素含量的快速测定方法,并对未知样品进行了含量预测.结果:建立的葛根素校正模型R2,RMSECV,RPD分别为0.980 1,0.131,7.09.对预测集样品预测平均相对偏差为3.2%.结论:该方法准确、快速、简便,可作为消渴丸中间产品质量检测和实时在线质量控制的方法.
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| 关 键 词： | 近红外光谱法 消渴丸 葛根素 |
| 收稿时间： | 2011/2/28 0:00:00 |
Rapid determination of puerarin in Xiaoke pill powder by near-infrared spectroscopy |
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| SU Biru,YE Bin,GENG Chunxian,SHI Meng and WU Changhai.Rapid determination of puerarin in Xiaoke pill powder by near-infrared spectroscopy[J].China Journal of Chinese Materia Medica,2011,36(6):672-675. |
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| Authors: | SU Biru YE Bin GENG Chunxian SHI Meng and WU Changhai |
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| Institution: | Guangzhou Zhongyi Pharmaceutical Co., Ltd., Guangzhou 510530, China;Guangzhou Zhongyi Pharmaceutical Co., Ltd., Guangzhou 510530, China;Guangzhou Zhongyi Pharmaceutical Co., Ltd., Guangzhou 510530, China;Guangzhou Zhongyi Pharmaceutical Co., Ltd., Guangzhou 510530, China;Guangzhou Zhongyi Pharmaceutical Co., Ltd., Guangzhou 510530, China |
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| Abstract: | Objective: To determine the content of puerarin in Xiaoke pill powder rapidly by near-infrared spectroscopy.Method: Near-infrared diffuse reflectance spectroscopy technology was used to collect NIR spectra of Xiaoke pills powder.With HPLC analysis values as reference,the fast determination method of puerarin was established with partial least squares(PLS).Result: The R2,RMSECV and RPD of the calibration model for puerarin were 0.980 1,0.131 and 7.09.The average relative deviation of the predication set was ... |
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| Keywords: | near-infrared spectroscopy Xiaoke pill puerarin |
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