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花椒毒酚对家兔离体回肠的作用
引用本文:胡晓,周俐,连其深,曾靖,杨敬格,赖飞.花椒毒酚对家兔离体回肠的作用[J].中国中药杂志,2001,26(1):56-58.
作者姓名:胡晓  周俐  连其深  曾靖  杨敬格  赖飞
作者单位:赣南医学院 药理教研室,
摘    要:目的 :研究花椒毒酚对家兔离体回肠平滑肌的作用及其与Ca2+的关系。方法 :采用常规回肠离体标本运动的实验方法。结果 :花椒毒酚 (XT)、维拉帕米 (Ver)可剂量依赖性地抑制次大剂量ACh ,5-HT所致的家兔离体回肠平滑肌收缩 ,非竞争性拮抗CaCl2 累积量 效曲线 ,pD2 ′分别为 4.69±0.03 ,6.35±0.10。XT10 μmol·L-1,Ver 0 .0 6 μmol·L-1可抑制ACh诱导的依内钙性收缩。XT 100 μmol·L-1尚可抑制ACh诱导的依外钙性收缩 ,但Ver 0.6μmol·L-1对此相收缩没有影响。结论 :XT具有钙拮抗作用 ,其作用方式不完全相同于Ver。

关 键 词:花椒毒酚  钙拮抗剂  乙酰胆碱  5羟色胺  回肠
文章编号:1001-5302(2001)01-0056-03
收稿时间:2000/3/21 0:00:00
修稿时间:2000年3月21日

Effect of Xanthnotoxol on Contractility of Isolated Rabbit Ileum
HU Xiao;ZHOU Li;LIAN Qi shen;ZHENG Jing;YANG Jing ge;LAI Fei.Effect of Xanthnotoxol on Contractility of Isolated Rabbit Ileum[J].China Journal of Chinese Materia Medica,2001,26(1):56-58.
Authors:HU Xiao;ZHOU Li;LIAN Qi shen;ZHENG Jing;YANG Jing ge;LAI Fei
Institution:Department of Pharmacology, Gannan Medecal College, Ganzhou 341000, Jiangxi, China.
Abstract:OBJECTIVE: To study the effect of Xanthnotoxol on contractility of isolated rabbit ileum and its relationship with Ca2+. METHOD: Routine experimental methods for isolated ileum were adopted. RESULT: Xanthnotoxol (XT) and Verapamil (Ver) inhibited the contraction of isolated rabbit ileum smooth muscle induced by submaximal concentrations of acetylcholine (ACh) and serotonim (5-TH), with a IC50 value (mumol.L-1) of 10.495 +/- 1.521, 0.428 +/- 0.001 and 18.132 +/- 1.627, 0.249 +/- 0.003, respectively. XT and Ver inhibited the contraction induced by Ca2+ after high K+ depolarization and for noncompetitively antagonist CaCl2 cumulative dose-response curve, the pD'2 value was 4.69 +/- 0.03 and 6.35 +/- 0.10, respectively. XT (10 mumol.L-1) and Ver(0.06 mumol.L-1) inhibited the contraction induced by ACh in Ca(2+)-free medium, while XT (100 mumol.L-1) but not Ver(0.6 mumol.L-1) inhibited the extracellar CA(2+)-dependent contraction induced by ACh. CONCLUSION: XT has a calcium-antagonistic effect which was not similar to that of Ver.
Keywords:xanthnotoxol  calcium antagonist  acetylcholine  serotonin  ileum
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