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车前子降糖活性部位的化学成分研究
引用本文:彭庆华,韩竹箴,童仁超,胡信权,杨启明,祁萌,石燕红,王峥涛,杨莉.车前子降糖活性部位的化学成分研究[J].中国中药杂志,2017,42(21):4150-4153.
作者姓名:彭庆华  韩竹箴  童仁超  胡信权  杨启明  祁萌  石燕红  王峥涛  杨莉
作者单位:上海中医药大学 中药研究所 中药标准化教育部重点实验室, 上海 201203,上海中医药大学 中药研究所 中药标准化教育部重点实验室, 上海 201203,上海中医药大学 中药研究所 中药标准化教育部重点实验室, 上海 201203,上海中医药大学 中药研究所 中药标准化教育部重点实验室, 上海 201203;上海中医药大学 中医方证与系统生物学研究中心, 上海 201203,上海中医药大学 中药研究所 中药标准化教育部重点实验室, 上海 201203,上海中医药大学 中药研究所 中药标准化教育部重点实验室, 上海 201203,上海中医药大学 中药研究所 中药标准化教育部重点实验室, 上海 201203,上海中医药大学 中药研究所 中药标准化教育部重点实验室, 上海 201203,上海中医药大学 中药研究所 中药标准化教育部重点实验室, 上海 201203;上海中医药大学 中医方证与系统生物学研究中心, 上海 201203
基金项目:国家"重大新药创制"科技重大专项(2012ZX09103-201-045);上海市科学技术委员会科技支撑项目(1540192400)
摘    要:该文研究车前子降糖活性部位的化学成分。前期研究表明车前子60%乙醇提取物对高脂饲料诱导糖尿病模型小鼠的血糖及糖耐量具有一定改善作用。该文进一步应用硅胶、ODS、Sephadex LH-20柱色谱,中压制备液相、薄层制备等色谱技术对车前子的60%乙醇提取物进行化学成分研究,共分离了8个化合物,并根据化合物的理化性质结合应用波谱技术鉴定了化合物结构,分别为车前子萜A(1)、iridolactone(2)、pedicularislacton(3)、rehmaglutin C(4)、京尼平苷酸(5)、p-hydroxylphenylglycerol(6)、4-(2-羟乙基)-1,2-苯二酚(7)、3-buten-2-one-4-3-(β-D-glucopyranosyloxy)-4-hydroxyphenyl](8)。其中,化合物1~5为环烯醚萜类,6~8为酚酸类。其中化合物1为新的天然产物,化合物2~4,6,8为首次从车前科植物中分离得到。

关 键 词:车前子  化学成分  降糖活性  环烯醚萜  酚酸类
收稿时间:2017/4/17 0:00:00

Chemical constituents from hypoglycemic active part of Plantaginis Semen
PENG Qing-hu,HAN Zhu-zhen,TONG Ren-chao,HU Xin-quan,YANG Qi-ming,QI Meng,SHI Yan-hong,WANG Zheng-tao and YANG Li.Chemical constituents from hypoglycemic active part of Plantaginis Semen[J].China Journal of Chinese Materia Medica,2017,42(21):4150-4153.
Authors:PENG Qing-hu  HAN Zhu-zhen  TONG Ren-chao  HU Xin-quan  YANG Qi-ming  QI Meng  SHI Yan-hong  WANG Zheng-tao and YANG Li
Institution:The Key Laboratory of Standardization of Chinese Medicines, Ministry of Education, Institute of Chinese Materia Medica of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China,The Key Laboratory of Standardization of Chinese Medicines, Ministry of Education, Institute of Chinese Materia Medica of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China,The Key Laboratory of Standardization of Chinese Medicines, Ministry of Education, Institute of Chinese Materia Medica of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China,The Key Laboratory of Standardization of Chinese Medicines, Ministry of Education, Institute of Chinese Materia Medica of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Center for Chinese Medical Therapy and Systems Biology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China,The Key Laboratory of Standardization of Chinese Medicines, Ministry of Education, Institute of Chinese Materia Medica of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China,The Key Laboratory of Standardization of Chinese Medicines, Ministry of Education, Institute of Chinese Materia Medica of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China,The Key Laboratory of Standardization of Chinese Medicines, Ministry of Education, Institute of Chinese Materia Medica of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China,The Key Laboratory of Standardization of Chinese Medicines, Ministry of Education, Institute of Chinese Materia Medica of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China and The Key Laboratory of Standardization of Chinese Medicines, Ministry of Education, Institute of Chinese Materia Medica of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Center for Chinese Medical Therapy and Systems Biology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Abstract:
Keywords:Plantaginis Semen  chemical constituents  hypoglycemic  iridoid  phenolic acid
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