| 桂枝茯苓胶囊及其活性成分组合物抗大鼠子宫肌瘤作用研究 |
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| 引用本文： | 衡晴晴,曹亮,李娜,丁岗,王振中,萧伟.桂枝茯苓胶囊及其活性成分组合物抗大鼠子宫肌瘤作用研究[J].中国中药杂志,2015,40(11):2206-2209. |
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| 作者姓名： | 衡晴晴 曹亮 李娜 丁岗 王振中 萧伟 |
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| 作者单位： | 江苏康缘药业股份有限公司, 江苏 连云港 222001;中药制药过程新技术国家重点实验室, 江苏 连云港 222001,江苏康缘药业股份有限公司, 江苏 连云港 222001;中药制药过程新技术国家重点实验室, 江苏 连云港 222001,江苏康缘药业股份有限公司, 江苏 连云港 222001;中药制药过程新技术国家重点实验室, 江苏 连云港 222001,江苏康缘药业股份有限公司, 江苏 连云港 222001;中药制药过程新技术国家重点实验室, 江苏 连云港 222001,江苏康缘药业股份有限公司, 江苏 连云港 222001;中药制药过程新技术国家重点实验室, 江苏 连云港 222001,江苏康缘药业股份有限公司, 江苏 连云港 222001;中药制药过程新技术国家重点实验室, 江苏 连云港 222001 |
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| 基金项目： | 国家"重大新药创制"科技重大专项(2013ZX09402203) |
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| 摘 要： | 为了研究桂枝茯苓胶囊及其活性成分组合物对大鼠子宫肌瘤模型的治疗作用,该研究以雌激素负荷法建立大鼠子宫肌瘤模型,灌胃给药后,观察大鼠子宫病理增生、子宫质量、血清中雌二醇(E2)和孕酮(P)水平等指标。结果表明,桂枝茯苓胶囊及活性成分组合物(75,150,300 mg·kg-1)均显著降低子宫肌瘤大鼠的子宫质量、子宫系数,抑制子宫平滑肌过度增殖,降低血清中雌二醇(E2)和孕酮(P)水平。该研究提示,活性成分组合物与桂枝茯苓胶囊一样具有明显的抗实验性大鼠子宫肌瘤作用,且具有量效关系,其作用机制主要是通过改善肌瘤子宫的病理学组织、降低血清雌二醇(E2)和孕酮(P)的含量,更进一步揭示了活性成分组合物可能是桂枝茯苓胶囊抗子宫肌瘤的效应物质基础。
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| 关 键 词： | 桂枝茯苓胶囊 雌二醇 孕酮 子宫肌瘤 |
| 收稿时间： | 2/5/2015 12:00:00 AM |
Effect of Guizhi Fuling capsule and combination of active ingredients on rats with uterine myoma |
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| HENG Qing-qing,CAO Liang,LI N,DING Gang,WANG Zhen-zhong and XIAO Wei.Effect of Guizhi Fuling capsule and combination of active ingredients on rats with uterine myoma[J].China Journal of Chinese Materia Medica,2015,40(11):2206-2209. |
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| Authors: | HENG Qing-qing CAO Liang LI N DING Gang WANG Zhen-zhong and XIAO Wei |
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| Institution: | Jiangsu Kanion Pharmarceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China,Jiangsu Kanion Pharmarceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China,Jiangsu Kanion Pharmarceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China,Jiangsu Kanion Pharmarceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China,Jiangsu Kanion Pharmarceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China and Jiangsu Kanion Pharmarceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China |
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| Abstract: | It is to observe the therapeutic action of Guizhi Fuling capsule and the combination of active ingredients on model rats with uterine leiomyoma. The hysteromyoma rats models was established in rats by loading eatrogen,to observe the effect on pathological condition of uterus,uterus wet weight,the content of estradiol and progesterone. Guizhi Fuling capsule and the combination of active ingredients remarkably decreased uterus weight,restrained the excess proliferation of the smooth muscle of uterus,decreased the estraiol and progesterone in blood serum. Guizhi Fuling capsule and the combination of active ingredients can restrain the formation of hysteromyoma in a dose-dependent manner. Perhaps the combination of active ingredients is the material foundation of antihysteromyoma. |
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| Keywords: | Guizhi Fuling capsule estradiol hysteromyoma uterine myoma |
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