| 雷公藤微乳凝胶中雷公藤甲素的药物动力学研究 |
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| 引用本文： | 管咏梅,严志宏,陈丽华,王森,赵益,朱卫丰,杨明.雷公藤微乳凝胶中雷公藤甲素的药物动力学研究[J].中国中药杂志,2011,36(2):216-219. |
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| 作者姓名： | 管咏梅 严志宏 陈丽华 王森 赵益 朱卫丰 杨明 |
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| 作者单位： | 现代中药制剂教育部重点实验室,江西,南昌,330004 |
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| 基金项目： | 国家"重大新药创制项目"科技重大专项(2008ZX09310-005);江西省教育厅科学技术研究平台建设项目(赣教技字[2005]02);2008年江西省卫生厅课题(2008A067) |
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| 摘 要： | 目的:建立雷公藤甲素在大鼠体内血药浓度的测定方法,研究雷公藤微乳凝胶经皮给药系统中雷公藤甲素的药代动力学过程.方法:以雷公藤片剂为对照,采用LC-MS-MS测定不同给药途径给药后,雷公藤甲素的血药浓度,采用药动学软件DAS处理得药动学参数.结果:雷公藤甲素在1-200ng呈良好的线性关系(r=0.996 7),最低检测限为0.5ug·L-1,该雷公藤甲素属一级动力学过程,雷公藤微乳凝胶中雷公藤甲素的主要药动学参数为:t1/2为(2.413.00)h,tmax(6.711.63)h,Cmax(82.9±17.63)ug·L-1,与片剂比较,微乳凝胶达峰时间较长,但可维持较长时间平稳的血药浓度;微乳凝胶和片剂的AUCot分别为(2 595.3±551.15),(209.9±25.34)h·ug·L-1,二者有极显著差异(P<0.01).结论:雷公藤经皮给药后,能在大鼠体内快速吸收,血药浓度平稳持久,雷公藤经皮给药具有合理性.
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| 关 键 词： | 微乳凝胶 雷公藤甲素 药代学 液相色谱-质谱/质谱联用 |
| 收稿时间： | 4/1/2010 12:00:00 AM |
Pharmacokinetics of triptoLide in Triptergium wilfordii microemulsion gel |
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| GUAN Yongmei,YAN Zhihong,CHEN Lihu,WANG Sen,ZHAO Yi,ZHU Weifeng and YANG Ming.Pharmacokinetics of triptoLide in Triptergium wilfordii microemulsion gel[J].China Journal of Chinese Materia Medica,2011,36(2):216-219. |
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| Authors: | GUAN Yongmei YAN Zhihong CHEN Lihu WANG Sen ZHAO Yi ZHU Weifeng and YANG Ming |
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| Institution: | Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China |
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| Abstract: | Objective: To establish a method of determinating the plasma concentration about the triptolide in rat in vivo.And to study the pharmacokinetics of triptolide in transdermal drug delivery system of Triptergium wilfordii microemulsion gel.Method: The T.wilfordii tablet was regarded as the control,the plasma concentration of triptolide was determined by LC-MS/MS after different route of administration,and the pharmacokinetic parameters were calculated by DAS.Result: The linear relation of triptolide was excel... |
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| Keywords: | microemulsion gel triptolide pharmacokinetics LC-MS/MS |
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