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川乌配伍白芍对炎症因子及自由基的影响
引用本文:秦林,彭欣,张少华,王玲,刘峰.川乌配伍白芍对炎症因子及自由基的影响[J].中国中药杂志,2000,25(6):370-373.
作者姓名:秦林  彭欣  张少华  王玲  刘峰
作者单位:山东中医药大学!山东济南250014(秦林,彭欣,张少华,王玲),山东大学!山东济南250100(刘峰)
基金项目:国家自然科学基金!资助项目 (39670 868)
摘    要:目的 :研究川乌与白芍配伍前后对炎症因子和自由基的作用。方法 :制备乌 芍配伍前后水煎液 ,采用大、小鼠炎症模型和SOD以及LPO检测方法进行观察比较。结果 :乌 芍配伍能增强各单味药尤其是川乌的抗炎作用 ,降低炎症过程中毛细血管通透性和炎症介质PGE2 的含量 ;减少川乌所致的血浆及肝组织LPO过量。结论 :本实验所显示的抑制炎症因子和清除自由基的结果 ,可能是二药配伍能增强单味药尤其是川乌抗炎祛风湿的重要机理之一。

关 键 词:川乌  白芍  配伍  炎症因子  自由基
收稿时间:1999/4/27 0:00:00

Influence of Monkshood Root-Peony Root Combination on Inflamation-induced Agents and Free Radicals
QIN Lin ;PENG Xin ;ZHANG Shao hua ;WANG Ling ;LIU Feng.Influence of Monkshood Root-Peony Root Combination on Inflamation-induced Agents and Free Radicals[J].China Journal of Chinese Materia Medica,2000,25(6):370-373.
Authors:QIN Lin ;PENG Xin ;ZHANG Shao hua ;WANG Ling ;LIU Feng
Institution:Shandong University of TCM, Jinan 250014, Shandong, China.
Abstract:Objective:To find out the effect of monkshood root and peony root on inflammation induced agents and free radicals when used separately and in combination.Method:Two drugs were made into decoctions separately and in combination,ip.,qd,for 7d, red blood cell SOD and serum LPO were analysed and the anti inflammatory actions were observed.Results:In an experimental rat model with inflamed paw edema induced by carrageenin or formaldehyde and in a mouse model with ear swelling induced by xylene,the anti inflammatory effect appeared stronger when the two drugs were used in combination,especially in comparison with the use of monkshood root alone.The exudation of blood capillaries and the contents of inflammatory medium PGE2 were lowered;The activity of SOD extracted from rat or mouse red blood cells was enhanced,and the serum LPO,which was high in level when monkshood root was used alone,could be declined when the two drugs were used in combination.Conclusion:The drug combination is more effective in inhibiting inflammation and scavenging free radicals.
Keywords:monkshood root  peony root  combination  anti inflammation  free radicals
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