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| 板蓝根提取物中总有机酸和水杨酸含量测定方法研究 | |
| 引用本文： | 马莉,唐健元,李祖伦,赵艳玲,廖庆文,肖小河,赵祥军,金城.板蓝根提取物中总有机酸和水杨酸含量测定方法研究[J].中国中药杂志,2006,31(10):804-806. |
| 作者姓名： | 马莉 唐健元 李祖伦 赵艳玲 廖庆文 肖小河 赵祥军 金城 |
| 作者单位： | 1. 解放军302医院解放军中药研究所,北京,100039;成都中医药大学,四川,成都,610075 2. 国家食品药品监督管理局,药品审评中心,北京,100038 3. 成都中医药大学,四川,成都,610075 4. 解放军302医院解放军中药研究所,北京,100039 |
| 基金项目： | 国家自然科学基金;国家中医药管理局科研项目 |
| 摘 要： | 目的：建立板蓝根提取物的质量控制方法。方法：采用酸碱滴定法测定总有机酸含量,并用反相高效液相色谱法测定板蓝根提取物中水杨酸的含量。结果：酸碱滴定法测得总有机酸含量为13.0%,RSD 2.0%；HPLC测得提取物中水杨酸的含量为0.22%,RSD 1.6%。结论：该方法能有效控制板蓝根提取物的质量。 |
| 关 键 词： | 板蓝根 提取物 总有机酸 水杨酸 含量测定 |
| 文章编号： | 1001-5302（2006）10-0804-03 |
| 收稿时间： | 2005-07-22 |
| 修稿时间： | 2005-07-22 |
Determination of total organic acids and salicylic acid in extract of Radix Isatidis |
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| MA Li ; TANG Jian-yuan ;LI Zu-lun ;LIAO Qing-wen ;XIAO Xiao-he;ZHAO Xiang-jun ;JIN Cheng.Determination of total organic acids and salicylic acid in extract of Radix Isatidis[J].China Journal of Chinese Materia Medica,2006,31(10):804-806. | |
| Authors: | MA Li ; TANG Jian-yuan ;LI Zu-lun ;LIAO Qing-wen ;XIAO Xiao-he;ZHAO Xiang-jun ;JIN Cheng |
| Institution: | 1.302 Hospital of PIA and PIA Institute of Chinese Materia Medica, Beijing 100039, China ; 2. Department of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China; 3. Center for Drug Evaluation, State Food and Drug Administration, Beijing 100038, China |
| Abstract: | Objective: To develop a quantitative method for determination of the total organic acids and salicyclic acid in the extract of Radix Isatidis.Method: The total organic acids were determined by acid-base titration and the salicylic acid was determined by HPLC.Result: It was shown that contents of total organic acids and salicylic acid in the extract of Radix Isatidis were 13.0% and 0.22%,respectively.Conclusion: The method can control the quality of this extract effectively and accurately. |
| Keywords: | Radix Isatidis extract total organic acids salicylic acid determination |
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