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| 鸦胆子油乳联合含铂类一线化疗方案治疗非小细胞肺癌的Meta分析 | |
| 引用本文： | 王权,王满才,何曦冉,高天明,曹慧,窦文婕,田金徽. 鸦胆子油乳联合含铂类一线化疗方案治疗非小细胞肺癌的Meta分析[J]. 中国中药杂志, 2012, 37(13): 2022-2029 |
| 作者姓名： | 王权 王满才 何曦冉 高天明 曹慧 窦文婕 田金徽 |
| 作者单位： | 1. 兰州大学循证医学中心,甘肃兰州730000;兰州大学第一临床医学院,甘肃兰州730000 2. 兰州大学循证医学中心,甘肃兰州730000;兰州大学第二临床医学院,甘肃兰州730000 3. 兰州大学循证医学中心,甘肃兰州,730000 |
| 基金项目： | 国家大学生创新性实验项目(222000860213);中央高校基本科研业务费专项(lzujbky-2011-133) |
| 摘 要： | 目的:该研究旨在评价鸦胆子油乳(brucea javanica oil emulsion,BJOE)联合含铂类一线化疗药物治疗非小细胞肺癌(non-small cell lung cancer,NSCLC)的疗效和安全性。方法:计算机检索Cochrane Library,PubMed,EMBASE,中国生物医学文献数据库,中国期刊全文数据库,中文科技期刊全文数据库,检索时间截止2011年2月,纳入有关鸦胆子油乳联合含铂类一线化疗药物治疗NSCLC的随机对照试验(randomized controlled trials,RCTs),由2名研究员分别独立提取数据和进行文献质量评价,并用RevMan5.1.2软件进行Meta分析。结果:共纳入22篇RCTs,共计病例数为1 512例。Meta分析结果显示,与单纯运用含铂类一线化疗方案相比,联合鸦胆子油乳能明显增加NSCLC患者化疗效果(RR=1.31,95%CI:1.18～1.45,P<0.000 01),提高生活质量(RR=1.78,95%CI:1.51～2.09,P<0.000 01),增强机体免疫力,降低骨髓抑制(OR=0.37,95%CI:0.27～0.51,P<0.000 01)和消化道毒副反应(OR=0.59,95%CI:0.44～0.80,P=0.000 7)。结论:鸦胆子油乳能提高非小细胞肺癌患者的化疗效果,改善生活质量,并降低含铂类化疗药物的毒副作用,值得临床借鉴。 |
| 关 键 词： | 鸦胆子 非小细胞肺癌 Meta分析 |
| 收稿时间： | 2011-10-03 |
Meta-analysis on treatment of non-small cell lung cancer with brucea javanica oil emulsion in combination with platinum-contained first-line chemotherapy |
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| WANG Quan,WANG Mancai,HE Xiran,GAO Tianming,CAO Hui,DOU Wenjie and TIAN Jinhui. Meta-analysis on treatment of non-small cell lung cancer with brucea javanica oil emulsion in combination with platinum-contained first-line chemotherapy[J]. China Journal of Chinese Materia Medica, 2012, 37(13): 2022-2029 | |
| Authors: | WANG Quan WANG Mancai HE Xiran GAO Tianming CAO Hui DOU Wenjie TIAN Jinhui |
| Affiliation: | Evidence-Based Medicine Center of Lanzhou University, Lanzhou 730000, China;The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China;Evidence-Based Medicine Center of Lanzhou University, Lanzhou 730000, China;The Second Clinical Medical College of Lanzhou University, Lanzhou 730000, China;Evidence-Based Medicine Center of Lanzhou University, Lanzhou 730000, China;The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China;Evidence-Based Medicine Center of Lanzhou University, Lanzhou 730000, China;The Second Clinical Medical College of Lanzhou University, Lanzhou 730000, China;Evidence-Based Medicine Center of Lanzhou University, Lanzhou 730000, China;Evidence-Based Medicine Center of Lanzhou University, Lanzhou 730000, China;The Second Clinical Medical College of Lanzhou University, Lanzhou 730000, China;Evidence-Based Medicine Center of Lanzhou University, Lanzhou 730000, China |
| Abstract: | Objective: To study the efficacy and safety of brucea javanica oil emulsion (BJOE) combining platinum-contained first-line chemotherapy in treating non small cell lung cancer (NSCLC). Method: Cochrane library,PubMed,EMBASE,VIP,CBM and CNKI were searched through computers. The search was finished in February,2011. Randomized controlled trials (RCTs) of BJOE combining platinum-contained first-line chemotherapy were included. Two researchers extracted data and assess literature quality separately,and made a meta-analyses by RevMan 5.1.2 software. Result: Totally 22 RCTs involving 1 512 patients were included. The Meta-analysis showed that compared with the pure application of platinum-contained first-line chemotherapy,the combination of BJOE and chemotherapy can enhance the near-term curative effect (RR=1.31,95% CI:1.18~1.45,P<0.000 01),improve the quality of life (RR=1.78,95%CI:1.51-2.09,P<0.000 01) and reduce the suppression of bone marrow (OR=0.37,95%CI:0.27-0.51,P<0.000 01) and the gastrointestinal reactions (OR=0.59,95%CI:0.44-0.80,P=0.000 7),with an improvement in organism immunity. Conclusion: The current evidence indicates that BJOE can enhance the chemotherapeutic effect on NSCLC patients,improve the quality of life and reduce adverse effect of platinum-contained chemotherapeutics and thus it is worth referring in clinic. |
| Keywords: | brucea javanica oil emulsion non-small cell lung cancer Meta-analysis |
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