| 虫草菌粉对致敏豚鼠肺功能和大鼠气道炎症反应的影响 |
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| 引用本文： | 林晓霞,谢强敏,沈文会,陈莹.虫草菌粉对致敏豚鼠肺功能和大鼠气道炎症反应的影响[J].中国中药杂志,2001,26(9):622-625. |
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| 作者姓名： | 林晓霞 谢强敏 沈文会 陈莹 |
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| 作者单位： | 浙江大学医学院国家药品监督局浙江呼吸药物研究实验室 |
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| 摘 要： | 目的 :探索人工发酵虫草菌粉防治支气管哮喘方面的新用途。方法 :测定肺功能和肺灌流液中嗜酸性粒细胞变化。结果 :虫草菌粉 5 g·kg-1对致敏豚鼠抗原攻击引起的肺阻力增高和动态肺顺应性降低以及致敏大鼠肺灌流液中嗜酸性粒细胞增多都有明显抑制作用 (P<0 .05)。结论 :结果提示虫草菌粉可用于哮喘缓解期的治疗或与其它平喘药合用。
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| 关 键 词： | 虫草菌粉 肺功能 抗炎 嗜酸性粒细胞 哮喘 |
| 文章编号： | 1001-5302(2001)09-0622-04 |
| 收稿时间： | 2001/3/23 0:00:00 |
| 修稿时间： | 2001年3月23日 |
Effects of Fermented Cordyceps Powder on Pulmonary Function in Sensitized Guinea Pigs and Airway Inflammation in Sensitized Rats |
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| LIN Xiao xia;XIE Qiang min;SHEN Wen hui;CHEN Ying.Effects of Fermented Cordyceps Powder on Pulmonary Function in Sensitized Guinea Pigs and Airway Inflammation in Sensitized Rats[J].China Journal of Chinese Materia Medica,2001,26(9):622-625. |
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| Authors: | LIN Xiao xia;XIE Qiang min;SHEN Wen hui;CHEN Ying |
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| Institution: | Zhejiang Respiratory Drugs Research Laboratory of State Drugs Administration of China, Zhejiang University College of Medicine, Hangzhou 310031, Zhejiang, China. |
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| Abstract: | Objective:To study Cordyceps (artificial fermented Cordyceps sinensis(Berk.)Sacc ) powderin the treatment of asthma in the animal models. Method:Pulmonary function and airway inflammation in vivo were investigated. Result:Cordyceps , 5g·kg-1 (ig), significantly inhibited bronchial challenge of ovalbumin induced change of RL and Cdyn (P<0.05) and inhibited antigen induced increase of eosinophils in the BALF of rats (P<0.05).Conclusion:The results suggested could be applied for the prevention and cure of asthma. |
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| Keywords: | Cordyceps sinensis pulmonary function lung resistance dynamic lung compliance antiinflammation eosinophil asthma |
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