| 娃儿藤内生真菌Talaromyces purpurogenus次生代谢产物研究 |
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| 引用本文： | 赵静怡,刘震,孙森凤,刘云宝.娃儿藤内生真菌Talaromyces purpurogenus次生代谢产物研究[J].中国中药杂志,2020(6):1368-1373. |
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| 作者姓名： | 赵静怡 刘震 孙森凤 刘云宝 |
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| 作者单位： | 中国医学科学院北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室 |
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| 基金项目： | 国家自然科学基金项目(21572276);中国医学科学院青年医学人才奖励项目(2018RC350007)。 |
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| 摘 要： | 通过硅胶柱色谱、中压ODS柱色谱和反相HPLC等多种色谱方法对娃儿藤内生真菌Talaromyces purpurogenus的次生代谢产物进行系统分离,运用NMR,MS,CD和旋光等现代波谱技术进行结构鉴定,共分离鉴定了8个化合物:(R)-2-5-(methoxycarbonyl)-4-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]acetic acid (1),(3S,4R)-3,4-dihydro-3,4-epoxy-5-hydroxynaphthalen-1(2H)-one (2),(-)-mitorubrinol (3),(-)-mitorubrin (4),(±)-asperlone A (5),terreusinone (6),verrucisidinol (7)和cerebroside C (8)。化合物1和2是新化合物。体外抗糖尿病试验结果显示,化合物1在浓度为10μmol·L-1时,对XOD酶的抑制率为69.9%。
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| 关 键 词： | 内生真菌 次生代谢产物 抗糖尿病 |
Investigation on secondary metabolites of endophytic fungus Talaromyces purpurogenus hosted in Tylophora ovate |
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| ZHAO Jing-yi,LIU Zhen,SUN Sen-feng,LIU Yun-bao.Investigation on secondary metabolites of endophytic fungus Talaromyces purpurogenus hosted in Tylophora ovate[J].China Journal of Chinese Materia Medica,2020(6):1368-1373. |
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| Authors: | ZHAO Jing-yi LIU Zhen SUN Sen-feng LIU Yun-bao |
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| Institution: | (State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China) |
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| Abstract: | Eight compounds,(R)-2-5-(methoxycarbonyl)-4-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]acetic acid(1),(3S,4R)-3,4-dihydro-3,4-epoxy-5-hydroxynaphthalen-1(2H)-one(2),(-)-mitorubrinol(3),(-)-mitorubrin(4),(±)-asperlone A(5), terreusinone(6), verrucisidinol(7) and cerebroside C(8) were isolated from the endophytic fungus Talaromyces purpurogenus by using various column chromatographic techniques. Their structures were identified by NMR, MS, CD and optical rotation. Compounds 1 and 2 were new compounds. Their anti-diabetic activities in vitro were evaluated, and compound 1 showed moderate inhibitory activity toward XOD at 10 μmol·L-1 with the inhibition rate of 69.9%. |
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| Keywords: | endophytic fungus secondary metabolites anti-diabetic |
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