| 缬草属植物的化学成分及生物活性研究概况 |
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| 引用本文： | 王茹静,黄青,雍妍,李鸿翔,张仕瑾,陈宝华,朱利霞,陈银,唐鑫,宋珊珊,董小萍,谭玉柱,张海.缬草属植物的化学成分及生物活性研究概况[J].中国中药杂志,2016,41(8):1405-1414. |
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| 作者姓名： | 王茹静 黄青 雍妍 李鸿翔 张仕瑾 陈宝华 朱利霞 陈银 唐鑫 宋珊珊 董小萍 谭玉柱 张海 |
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| 作者单位： | 成都中医药大学 药学院 中药材标准化教育部重点实验 四川省中药资源系统研究与开发利用 重点实验室—省部共建国家实验室培育基地, 四川 成都 611137,成都中医药大学 药学院 中药材标准化教育部重点实验 四川省中药资源系统研究与开发利用 重点实验室—省部共建国家实验室培育基地, 四川 成都 611137,成都中医药大学 药学院 中药材标准化教育部重点实验 四川省中药资源系统研究与开发利用 重点实验室—省部共建国家实验室培育基地, 四川 成都 611137,成都中医药大学 药学院 中药材标准化教育部重点实验 四川省中药资源系统研究与开发利用 重点实验室—省部共建国家实验室培育基地, 四川 成都 611137,成都中医药大学 药学院 中药材标准化教育部重点实验 四川省中药资源系统研究与开发利用 重点实验室—省部共建国家实验室培育基地, 四川 成都 611137,成都航天医院, 四川 成都 610100,成都中医药大学 药学院 中药材标准化教育部重点实验 四川省中药资源系统研究与开发利用 重点实验室—省部共建国家实验室培育基地, 四川 成都 611137,成都中医药大学 药学院 中药材标准化教育部重点实验 四川省中药资源系统研究与开发利用 重点实验室—省部共建国家实验室培育基地, 四川 成都 611137,成都中医药大学 药学院 中药材标准化教育部重点实验 四川省中药资源系统研究与开发利用 重点实验室—省部共建国家实验室培育基地, 四川 成都 611137,成都中医药大学 药学院 中药材标准化教育部重点实验 四川省中药资源系统研究与开发利用 重点实验室—省部共建国家实验室培育基地, 四川 成都 611137,成都中医药大学 药学院 中药材标准化教育部重点实验 四川省中药资源系统研究与开发利用 重点实验室—省部共建国家实验室培育基地, 四川 成都 611137,成都中医药大学 药学院 中药材标准化教育部重点实验 四川省中药资源系统研究与开发利用 重点实验室—省部共建国家实验室培育基地, 四川 成都 611137,成都中医药大学 药学院 中药材标准化教育部重点实验 四川省中药资源系统研究与开发利用 重点实验室—省部共建国家实验室培育基地, 四川 成都 611137 |
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| 基金项目： | 国家基础科学培养基金项目(J13100340-11);四川省教育厅重点项目(15ZA0093);成都中医药大学科技发展基金项目(ZRQN1440);中药药效物质基础研究与创新中药发现四川省青年科技创新研究团队项目(2016TD0006);四川省中医药管理局基金项目(2016Q049) |
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| 摘 要： | 结合国内外文献综述了缬草属植物化学成分的研究进展,并对该属药用植物的药理活性进行了总结。缬草属植物除含有一定的挥发油外,化学成分主要集中于单萜类、倍半萜类、木脂素类、黄酮类、生物碱类等。其中单萜类成分主要以环烯醚萜类化合物为主,根据其结构是否裂环分为环戊烷环环烯醚萜和裂环环烯醚萜。药理研究表明该属植物具镇静、解痉、抗抑郁、抗肿瘤、抗A1阿糖腺苷受体性和细胞毒性,并对心血管有一定作用。鉴于目前缺少对缬草属研究的系统回顾和综述,该文对近年来发表的缬草属研究文献进行整理和分析,为其进一步开发利用提供依据。
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| 关 键 词： | 缬草属 化学成分 药理活性 |
| 收稿时间： | 2015/12/3 0:00:00 |
Studies on chemical constituents of Valeriana plants and their biological activities |
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| WANG Ru-jing,HUANG Qing,YONG Yan,LI Hong-xiang,ZHANG Shi-jing,CHEN Bao-hu,ZHU Li-xi,CHEN Yin,TANG Xin,SONG Shan-shan,DONG Xiao-ping,TAN Yu-zhu and ZHANG Hai.Studies on chemical constituents of Valeriana plants and their biological activities[J].China Journal of Chinese Materia Medica,2016,41(8):1405-1414. |
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| Authors: | WANG Ru-jing HUANG Qing YONG Yan LI Hong-xiang ZHANG Shi-jing CHEN Bao-hu ZHU Li-xi CHEN Yin TANG Xin SONG Shan-shan DONG Xiao-ping TAN Yu-zhu and ZHANG Hai |
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| Institution: | Pharmacy College, Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China,Pharmacy College, Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China,Pharmacy College, Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China,Pharmacy College, Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China,Pharmacy College, Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China,Chengdu aerospace hospital, Chengdu 610100, China,Pharmacy College, Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China,Pharmacy College, Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China,Pharmacy College, Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China,Pharmacy College, Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China,Pharmacy College, Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China,Pharmacy College, Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China and Pharmacy College, Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China |
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| Abstract: | The recent progresses on chemical components and pharmacological activities of the genus Valeriana were summarized.Besides-essential oil, the chemical composition of Valeriana is mainly focused on monoterpenoids,sesquiterpenoids,lignans, flavonoids, alkaloids, etc. Iridoids are the main chemical components ofmonoterpenoids. There are two types ofiridoidson the basis of the cyclopentane open or not. The Valeriana has been drawmuch attention for their significant sedation,spasmolysis,antidepression,antitumor, against adenosine A1 receptors and cytotoxicityactivity,and had certain function for cardiovascular disease treatment. Given to the fact of the lack of systematic review and summary of studies on the Valeriana, we summarized and analyze the study literatures on the pharmacological activity of Valeriana in recent years, and providedsome basisfor further study. |
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| Keywords: | Valeriana chemical components pharmacological activities |
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