黄连解毒汤模拟体系的超滤膜过程研究

目的:以黄连解毒汤模拟体系为研究对象,探讨中药水提液超滤过程污染机制,为中药膜分离技术应用系统的优化设计奠定基础.方法:采用系统模拟的方法,以超滤膜过程中通量变化、膜污染度、成分截留率、小分子物质吸附速率和吸附量等为指标,研究黄连解毒汤复方中小分子药效物质和共性高分子物质的超滤行为及相互影响.结果:黄连解毒汤模拟体系中,小檗碱和栀子苷PS5K超滤膜透过率在90%以上,淀粉、果胶、蛋白质3种高分子物质的截留率为100%;但模拟溶液中由于高分子物质的存在造成小檗碱和栀子苷的膜透过率大大降低,膜污染和膜通量衰减加剧;小檗碱和栀子苷的膜吸附行为也因为高分子物质的存在而发生了改变.结论:黄连解毒汤复方溶液中,高分子物质的存在是造成超滤膜污染和药效物质损失的主要因素,其中主要污染物是淀粉和果胶.

UF process of model system of Huanglianjiedu decoction

Abjective: The UF process of model systerm of Huanglianjiedu decoction is researched in the study to lay a foundation for the exploring of the substance foudation of membrane fouling, and for the the optimal design of membrane technology in the production of chinese drugs preparation. Method: Using the membrane flux, fouling degree of membrane, preserving degree and adsorption capacity of effective materials as guide line, trying to find out the influence of macromolecule materials on Small molecules in Huanglianjiedu decoction. Result: That the two small molecules berberine and gardenoside in Huanglianjiedu decoction have high permeation rate. But for the reasons of interaction of macromolecule, the permeation rate of small molecules reduces greatly, membrane fouling and membrane flux decline intensify. Conclusion: Starch and pectin are the two main macromolecule materials in Huanglianjiedu decoction which cause membrane fouling and flux falling.