复方长循环肿瘤靶向制剂的研究进展

肿瘤一直是世界医疗界难以攻克的难题，其发生发展过程中微环境多种因素的干预，使常规药物的效果有限。复方长循环靶向制剂以其高效、低毒、多靶点协同作用的特点，在改善肿瘤微环境，提高肿瘤治疗效果方面表现出特有的优势，现已逐渐成为国内外研究的热点。该文通过查阅近年来国内外专业文献，对不同载体复方长循环肿瘤靶向制剂的体内外研究现状进行综述，以期为复方长循环肿瘤靶向制剂的发展提供新的思路和方法。

Advance in studies on long-circulating tumor targeted compound preparations

Tumor has long been a hard-nut problem in the world medical field. The effect of the conventional drugs is very limited because of the intervention of multiple micro-environmental factors during the occurrence and progression of tumors. With the characteristics of high efficiency, low toxicity and multi-targets synergistic effect, the long-circulating tumor targeted compound preparations show its unique advantages in improving tumor microenvironment and enhancing the therapeutic effect of treatment, thus it has gradually become a hotspot of studies both at home and abroad. Through consulting a great number of professional literatures at home and abroad in recent years, the authors summarized the current studies in vitro and in vivo on long-circulating tumor targeted compound preparations in different carriers, in the expectation of providing new ideas and methods for the development of long-circulating tumor targeted compound preparations.