基因芯片技术与中药研究——中药基因组学

中药多成分、多途径、多靶点的作用特点决定了其系统化研究的趋势,基因芯片技术以其高通量、并行、高内涵的优势介入了现代中药研究。作者回顾了近3年来用于探索中药作用靶点、药物有效部位、中药材鉴定、新药物筛选等方面的新进展,结合中医学的理论指导,提出“中药基因组学”的发展趋势,以求探索中医药研究的纵深发展。

Microarray and research of Chinese medications:pharmcogenomics of Chinese medications

The mechanism of Chinese medications have some characteristic such as multi-pathway, multi-components, multi-targets and so on, which decide the direction of systems research. In the recent years, microarrays be concerned with the relative field of Chinese medications for its superiority of highthough,parallel and high-density. This paper mainly generalize the approach of these methods in the recent three years, such as finding effective target of Chinese medications,effective part of Chinese medications,checkup of Chinese medications, screening new drugs and so on.We suggest the concept of Pharmacogenomics of Chinese medications with the guidance of the theory of Chinese medications for further development of Chinese medications.