大黄橐吾的化学成分研究Ⅱ

目的:从菊科橐吾属植物大黄橐吾的根及根茎中提取分离活性成分,为其资源开发提供科学依据。方法:以90%乙醇提取,采用硅胶柱色谱、凝胶柱色谱、重结晶等方法分离纯化化合物,根据理化常数及波谱数据进行结构鉴定。结果:共分离鉴定了9个化合物,分别为Δ^12,13-羽扇豆醇(1),异莨菪亭(2),isoline(3),duciformine(4),(2S,3S,4R)-鞘氨醇-(2′R)-Δ^5′,6′(E)-2′-羟基正二十四碳酰胺(5),正二十四碳酸(6),正二十四酸单甘油酯(7),反式-阿魏酸正二十二酯(8),反式-咖啡酸正二十二酯(9)。结论:化合物1,2,5~7为首次自该植物中分离得到,其中化合物2,5~7为首次自橐吾属中分得。

Study on chemical constituents in roots and rhizomes of Ligularia duciformsⅡ

OBJECTIVE: To study the chemical constituents in roots and rhizomes of Ligularia duciforms. METHOD: 90% ethanol extract was isolated and purified by silica gel and sephadex LH-20 column chromatography, the structures of compounds were identified by physicochemical properties and spectral analysis. RESULT: Nine compounds were isolated and identified as lupeol (1), isoscopoletin (2), isoline (3), duciformine (4), (2S, 3S, 4R)-sphinganine-(2'R)-delta5',6' (E)-2'-hydroxytetracosanoylamino (5), tetracosanoic acid (6), tetracosanoicacid glyceride (7), (E)-docosyl ferulate (8), (E)-docosyl caffeate (9). CONCLUSION: Compounds 1, 2, 5-7 were isolated for the first time from this plant, and the compound 2, 5-7 were isolated firstly from the genus Ligularia.