川乌配伍白芍的抗炎作用特点研究

目的 :比较川乌与白芍配伍前后的抗炎作用 ,探讨配伍后的抗炎增效特点。方法 :采用大鼠甲醛、角叉菜胶、佐剂所致的关节炎模型 ,以及其他炎症模型 (如大鼠棉球肉芽炎症、小鼠二甲苯耳壳肿胀和腹腔毛细血管通透性等 )。结果 :川乌的抗炎作用较弱 ,而白芍和川乌配伍白芍均有明显的抗炎作用。药物配伍的抗炎作用特点 ,第一 ,对大鼠甲醛性和佐剂继发性关节炎模型 ,二药配伍后的抗炎作用明显优于各单味药 (P<0.005,P<0.05) ;而对角叉菜胶性关节炎以及其他炎症模型 ,二药配伍前后的抑制率无明显差异 (P>0.05)。第二 ,配伍组 1∶2低剂量组 ,在减少川乌剂量后其抗炎作用 (主要对大鼠佐剂继发性、甲醛性关节炎症模型 )仍明显强于川乌组 (P<0.005) ,也明显强于白芍组 (P<0.05)。结论 :川乌配伍白芍的抗炎作用有选择性增效特点。

Studies on the Anti-inflammation Effect of the TCM Prescription of a Combination of Monkshood Root with Peony Root

OBJECTIVE: To make a comparison between the single and combined use of Monkshood Root and Peony Root to observe the anti-inflammation effect in the experimental animals. METHOD: The experimental inflammatory models were adopted, i.e. adjuvant-induced polyarthritis carrageenan-induced or formaldehyde-induced rat paw edema, and cotton pellet-induced granuloma formation in rats xylene-induced mouse ear edema, exudation of abdominal blood capillaries of mice, etc. RESULT: The anti-inflammafion effect of Monkshood Root was weaker than that of Peony Root or Peony Root combined with Monkshood Root. It was found that anti-inflammation effect with the drug-cooperation was enhanced more significantly in the formaldehyde-induced or adjuvant-induceed arthritis models than in the carrageenan-induced rat paw edema and other inflammatory models either in the large dosage of 1:1 proportion or in the small dosage of 1:2 proportion. CONCLUSION: The drug-cooperation has a good selective and synergic effect on anti-inflammation.