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糖尿病肾病肾组织炎症信号通路p38MAPK的调节机制及中药的干预作用
引用本文:陈好利,万毅刚,赵青,黄燕如,史喜苗,孟宪杰,姚建.糖尿病肾病肾组织炎症信号通路p38MAPK的调节机制及中药的干预作用[J].中国中药杂志,2013,38(14):2268-2272.
作者姓名:陈好利  万毅刚  赵青  黄燕如  史喜苗  孟宪杰  姚建
作者单位:南京中医药大学 中西医结合鼓楼临床医学院, 江苏 南京 210008;南京大学 医学院 附属鼓楼医院 中医科, 江苏 南京 210008;宜春市中医院, 江西 宜春 336000;南京中医药大学 中西医结合鼓楼临床医学院, 江苏 南京 210008;南京中医药大学 中西医结合鼓楼临床医学院, 江苏 南京 210008;南京中医药大学 中西医结合鼓楼临床医学院, 江苏 南京 210008;Department of Molecular Signaling University of Yamanashi, Yamanashi, Japan 409-3898
基金项目:南京市卫生青年人才培养工程项目;江苏省中医药局科技项目(LZ11116)
摘    要:在糖尿病肾病(diabetic nephropathy,DN)的发展过程中,炎症相关信号通路——p38丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)通路与肾组织损伤密切相关。一方面,高血糖、血流动力学异常、氧化应激以及前炎症因子等多种因素在上游激活p38MAPK信号通路;另一方面,活化的p38MAPK信号通路进一步诱导下游炎症细胞活化,促进炎症介质表达,增加炎症因子产生,最终,导致肾组织炎症性损伤。中药对p38MAPK信号通路的干预作用是通过多途径实现的,主要包括抑制炎症因子表达、调节磷酸化p38MAPK(phosphorylated p38MAPK,p-p38MAPK)表达、减少致纤维化因子表达等。

关 键 词:糖尿病肾病  中药  p38丝裂原活化蛋白激酶  信号通路
收稿时间:5/4/2013 12:00:00 AM

Regulative mechanism of renal inflammatory-related p38MAPK signaling pathway in diabetic nephropathy and interventional effects of Chinese herbal medicine
CHEN Hao-li,WAN Yi-gang,ZHAO Qing,HUANG Yan-ru,SHI Xi-miao,MENG Xian-jie and YAO Jian.Regulative mechanism of renal inflammatory-related p38MAPK signaling pathway in diabetic nephropathy and interventional effects of Chinese herbal medicine[J].China Journal of Chinese Materia Medica,2013,38(14):2268-2272.
Authors:CHEN Hao-li  WAN Yi-gang  ZHAO Qing  HUANG Yan-ru  SHI Xi-miao  MENG Xian-jie and YAO Jian
Institution:Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210008, China;Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China;Yichun Hospital of Traditional Chinese Medicine, Yichun 336000, China;Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210008, China;Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210008, China;Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210008, China;Department of Molecular Signaling University of Yamanashi, Yamanashi 409-3898, Japan
Abstract:It is reported,in the process of diabetic nephropathy(DN),inflammatory-related p38 mitogen-activated protein kinase(MAPK)signaling pathway has a close relationship with renal injury.On the one hand,many factors in the upstream including hyperglycemia,abnormal hemodynamics,oxidative stress,and pro-inflammatory cytokines could activate p38MAPK signaling pathway.On the other hand,the activated p38MAPK signaling pathway could lead to renal damage via activating inflammatory cells,inducing the expression of inflammatory mediators,and intervening cytokines production.CHM could intervene p38MAPK signaling pathway through multi-ways,including inhibiting inflammatory cytokines expression,regulating phosphorylated p38MAPK(p-p38MAPK)expression,and reducing fibrogenic factors expression.
Keywords:diabetic nephropathy  Chinese herbal medicine  p38 mitogen-activated protein kinase  signaling pathway
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