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知母中的生物碱
引用本文:沈莉,戴胜军,赵大洲.知母中的生物碱[J].中国中药杂志,2007,32(1):39-41.
作者姓名:沈莉  戴胜军  赵大洲
作者单位:1. 中国海洋大学,山东,青岛,266003;烟台大学药学院,山东,烟台,264005
2. 烟台大学药学院,山东,烟台,264005
3. 山东绿叶制药有限公司,山东,烟台,264003
摘    要:目的:研究知母中的生物碱成分.方法:Sephdex LH-20,Rp-18及硅胶色谱柱分离纯化,根据理化性质和光谱数据鉴定结构.结果:分离鉴定了6个生物碱,分别为aurantiamide acetate(1)、环(酪-亮)二肽(2)、香豆酰基酪胺(3)、N-反式阿魏酰基酪胺(4)、N-顺式阿魏酰基酪胺(5)、烟酸(6).结论:化合物1~5为首次从百合科植物中分离得到,化合物1~6为首次从知母中分离得到.

关 键 词:知母  化学成分  生物碱
文章编号:1001-5302(2007)01-0039-03
收稿时间:2006-04-17
修稿时间:2006-04-17

Studies on the alkaloids of Anemarrhena asphodeloides
SHEN Li;DAI Sheng-jun;ZHAO Da-zhou.Studies on the alkaloids of Anemarrhena asphodeloides[J].China Journal of Chinese Materia Medica,2007,32(1):39-41.
Authors:SHEN Li;DAI Sheng-jun;ZHAO Da-zhou
Institution:1. Ocean University of China, Qingdao 266003, China ; 2. School of Pharmacy, Yantai University, Yantai 264005, China ; 3. Shandong Luye Pharmaceutical Co. , Ltd, Yantai 264003, China
Abstract:Objective: To investigate the alkaloids of Anemarrhena asphodeloides.Method: The compounds were isolated and purified by Sephadex LH-20,Rp-18 and silica gel column chromatography.Their chemical structures were elucidated on the basis of physicochemical properties and spectral data(IR,FAB-MS,~(1)H-NMR,and ~(13)C-NMR).Result: Six compounds were isolated and identified as: aurantiamide acetate(1),cyclo(Tyr-Leu)(2),N-p-coumaroyltyramine(3), N-trans-feruloyltyramine(4),N-cis-feruloyltyramine(5),and nicotinic acid(6),respectively.Conclusion: For the first time,compounds 1-5 were separated from Liliacae plant,and compounds 1-6 were obtained from this plant.
Keywords:Anemarrhena asphodeloides  chemical constituents  alkaloid
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