益妇宁胶囊对去势高血脂模型大鼠血脂水平的影响

目的:观察益妇宁(YFN)胶囊对去势高血脂大鼠血脂水平的影响。方法:56只SD雌性大鼠随机分为7组:正常组、模型对照组、乙烯雌酚片组、血脂康组、YFN高、中、低剂量组。造模成功后喂高脂饲料并给药3周,测定大鼠体重及肝指数,并用试剂盒检测血脂五项(TC,TG,HDL-C,LDL-C,VLDL)及酶(HP,LPL,总脂酶)的水平。结果:模型组大鼠的体重、肝指数较正常组明显升高(P<0.05),YFN能明显降低去势高脂大鼠血清TG,TC,LDL-C水平(P<0.05),明显升高HP,LPL,总脂酶的水平(P<0.05)。结论:YFN可以改善去势高血脂大鼠血脂水平。

Effects of Yifuning capsule on blood lipids of ovariectomized hyperlipidemia rats

Objective: To observe the effects of Yifuning(YEN) capsule on blood lipids of ovariectomized hyperlipidemia rats.Method:Fifty-six female mature sprague-dawley rats were randomized into 7 groups: normal control group,model control group,diethylstilbestrol tablets(DT) group,Xuezhikang group,YFN high,middle and low dose groups.The ovariectomized rats were fed on high fat diet and administrated with the drugs for 3 weeks,then were killed and estimated body weight,liver index and five items of blood lipid(TC,TG,HDL-C,LDL-C,VLDL) by test kit.Enzyme(such as HP,LDL,and whole lipase) was detected too.Result: The weight and liver index of model control group increased obviously as compared with normal group.YFN could reduce TG,TC,and LDL-C(P<0.05) of ovariectomized hyperlipidemia rats obviously and increase HP,LDL and whole lipase(P<0.05) on the other hand.Conclusion:YFN can ameliorate blood lipids of ovariectomized hyperlipidemia rats.