| 辣椒碱立方液晶纳米粒的制备及体外评价 |
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| 引用本文： | 彭新生,周艳芳,韩珂,覃玲珍,吴传斌.辣椒碱立方液晶纳米粒的制备及体外评价[J].中国中药杂志,2014,39(4):644-647. |
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| 作者姓名： | 彭新生 周艳芳 韩珂 覃玲珍 吴传斌 |
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| 作者单位： | 广东医学院 药学院, 广东 东莞 523808;广东医学院 药学院, 广东 东莞 523808;广州医科大学 第二附属医院, 广东 广州 510260;中山大学 药学院, 广东 广州 510006;中山大学 药学院, 广东 广州 510006 |
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| 基金项目： | 国家自然科学基金项目（81001643，81173002，81202477）；广东省及东莞市科技计划项目（2011B031700058，2011108102020） |
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| 摘 要： | 该文主要探讨辣椒碱立方液晶纳米粒的体外透皮吸收性能，采用改良的Franz扩散池体外透皮实验技术，对辣椒碱立方液晶纳米粒及其软膏剂进行体外透皮扩散实验。实验结果表明立方液晶纳米粒制剂相对于辣椒碱软膏剂而言，无促进药物渗透作用。但立方液晶纳米粒制剂中的辣椒碱在角质层、表皮层与真皮层中的滞留量明显高于软膏剂（P<0.01），立方液晶纳米粒作为皮肤局部给药的载体可提高作用部位的有效药物浓度，皮肤靶向性好。
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| 关 键 词： | 立方液晶纳米粒 辣椒碱 透皮扩散 皮肤靶向 |
| 收稿时间： | 2013/8/30 0:00:00 |
Preparation and in vitro study on diffusion of capsaicin cubosome |
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| PENG Xin-sheng,ZHOU Yan-fang,HAN Ke,QIN Ling-zhen and WU Chuan-bin.Preparation and in vitro study on diffusion of capsaicin cubosome[J].China Journal of Chinese Materia Medica,2014,39(4):644-647. |
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| Authors: | PENG Xin-sheng ZHOU Yan-fang HAN Ke QIN Ling-zhen and WU Chuan-bin |
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| Institution: | School of Pharmaceutical Sciences, Guangdong Medical College, Dongguan 523808, China;School of Pharmaceutical Sciences, Guangdong Medical College, Dongguan 523808, China;The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China;School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China;School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China |
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| Abstract: | This study was to investigate the permeability and absorbability of capsaicin cubosome across abdominal skin of the SD rats in vitro. Diffusion of capsaicin cubosome and cream was performed with the modified Franz diffusion cell technique. The capsaicin cubosome showed no enhancement of skin permeation within 24 hours. However, the deposition amounts of capsaicin in the rat skin in the cubosome group was markedly higher than those in the commercial cream group (P<0.01). Cubosome showed excellent characetristic of skin-targed which could be a good carrier for the local transdermal drug delivery system. |
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| Keywords: | cubosome capsaicin diffusion skin-targeted |
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