| 粗壮润楠中的木脂素类成分 |
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| 引用本文： | 卜鹏滨,里艳茹,姜明,王晓良,王芳,林生,朱承根,石建功.粗壮润楠中的木脂素类成分[J].中国中药杂志,2013,38(11):1740-1746. |
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| 作者姓名： | 卜鹏滨 里艳茹 姜明 王晓良 王芳 林生 朱承根 石建功 |
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| 作者单位： | 天然药物活性物质与功能国家重点实验室,中国医学科学院北京协和医学院药物研究所,北京100050 |
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| 基金项目： | 国家自然科学基金项目(30825044,20932007);国家"重大新药创制"科技重大专项(2011ZX09307-002-01) |
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| 摘 要： | 通过萃取、正相硅胶、Sephadex LH-20、中压柱色谱以及反相HPLC柱色谱等多种分离方法相结合,从粗壮润楠树皮乙醇提物中分离得到18个木脂素类化合物；通过质谱和核磁共振等波谱学分析方法鉴定结构为:异落叶松脂素9'-0-β-D-吡喃木糖苷(1),5'-甲氧基异落叶松脂素9 '-O-β-D-吡喃木糖苷(2),南烛木树脂酚9 '-O-β-吡喃木糖苷(3),(+)-(8S,8'S)-4,4 '-二羟基-3,3 ',5,5'-四甲氧基木脂烷-9,9'-二醇9-O-β-D-吡喃木糖苷(4),南烛木树脂酚(5),内消旋二氢愈创木脂酸(6),(+)-(8S,8 'R)-3',4,4'-三羟基-3'-甲氧基木脂烷(7),(8S,8'R)-4'-羟基-3,3',4-三甲氧基木脂烷(8),(+)-愈创木素(9),异愈创木素(10),(-)-(7'R,8R,8 'R)-4,4'-二羟基-3,3',5-三甲氧基-2,7'-环木脂烷(11),翼梗五味子木脂素B(12),(-)-(7S,7'S,8R,8'R)-4,4'-二羟基-3,3',5,5'-四甲氧基-7,7'-环氧木脂素-9,9'-二醇(13),(+)-(7R,8R,7'E)-4-羟基-3,5'-二甲氧基-7,4'-环氧-8,3'-氧新木脂素-7'-烯(14),甘密树皮素B(15),桢楠素Ⅰ(16),(-)-松脂素(17)和(-)-丁香树脂酚(18).以上化合物均为首次从该植物中分离得到.经体外活性筛选,在10 μmol·L-1时,化合物17对小鼠腹腔巨噬细胞分泌NO具有较强的抑制活性,抑制率为72.2％.
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| 关 键 词： | 粗壮润楠 木脂素苷 木脂素苷元 抑制小鼠腹腔巨噬细胞分泌NO活性 |
| 收稿时间： | 2013/1/29 0:00:00 |
Lignans from Machilus robusta |
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| BU Peng-bin,LI Yan-ru,JIANG Ming,WANG Xiao-liang,WANG Fang,LIN Sheng,ZHU Cheng-gen and SHI Jian-gong.Lignans from Machilus robusta[J].China Journal of Chinese Materia Medica,2013,38(11):1740-1746. |
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| Authors: | BU Peng-bin LI Yan-ru JIANG Ming WANG Xiao-liang WANG Fang LIN Sheng ZHU Cheng-gen and SHI Jian-gong |
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| Institution: | State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China |
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| Abstract: | |
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| Keywords: | Machilus robusta lignan glycosides lignan aglycones inhibitory activity of NO secretion of mouse peritoneal macrophages |
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