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黄葵胶囊对阿霉素肾病肾组织炎症信号通路p38MAPK的干预作用
引用本文:赵青,万毅刚,孙伟,王朝俊,魏晴雪,陈好利,孟宪杰.黄葵胶囊对阿霉素肾病肾组织炎症信号通路p38MAPK的干预作用[J].中国中药杂志,2012,37(19):2926-2934.
作者姓名:赵青  万毅刚  孙伟  王朝俊  魏晴雪  陈好利  孟宪杰
作者单位:1. 南京中医药大学 中西医结合鼓楼临床医学院,江苏 南京,210029
2. 南京大学 医学院 附属鼓楼医院 中医科,江苏 南京,210008
3. 江苏省中医院 肾内科,江苏 南京,210029
4. 昆山市中医院,江苏 昆山,215300
基金项目:南京市卫生青年人才培养工程项目;江苏高校优势学科建设工程项目
摘    要:目的:阐明黄蜀葵花(Abelmoschus manihot,AM)提取物制剂——黄葵胶囊(Huangkui capsule,HKC)调节阿霉素肾病(adriamycin-induced nephropathy,ADRN)模型p38丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)信号通路从而改善肾组织炎症性损伤的机制.方法:将19只SD大鼠随机分为假手术组、对照组和HKC组.对HKC组和对照组大鼠行右侧肾摘除术,并在4周内分2次经颈静脉注射阿霉素(adriamycin,ADR)建立ADRN模型.HKC组大鼠于第2次注射ADR后经灌胃给予HKC悬浊液,对照组和假手术组大鼠同时经灌胃给予蒸馏水,共干预4周.在HKC和蒸馏水干预前和干预后第1,2,3,4周末,分别称量大鼠体重,并检测24 h尿蛋白排泄量(24 h urinary protein excretion,Upro).肾摘除术后第8周末处死全部大鼠,抽取血液,摘除左肾并称重,观察血清生化指标、肾小球形态特征、肾小球α-平滑肌肌动蛋白(α-smooth muscle actin,α-SMA)、Ⅰ型胶原(collagen type Ⅰ)表达特征、肾小球巨噬细胞(macrophage,Mφ)浸润特征等,并且检测肾组织转化生长因子(transforming growth factor,TGF)-β1,p38MAPK,磷酸化p38MAPK(phosphorylated p38MAPK,p-p38MAPK)蛋白相对表达量.结果:与对照组大鼠比较,HKC改善了模型鼠的蛋白尿和血清白蛋白(albumin,Alb),抑制了模型鼠系膜细胞(mesangial cell,MC)增殖、细胞外基质(extracellular matrix,ECM)及其胶原成分沉积,减轻了肾小球α-SMA,Ⅰ型胶原表达,减轻了肾小球ED1+,ED3+浸润,下调了模型鼠肾组织TGF-β1,p-p38MAPK蛋白表达.结论:HKC在体内具有减轻肾组织炎症性损伤的作用;HKC通过下调肾组织p38MAPK信号通路中关键信号分子——p-p38MAPK的蛋白表达,干预其相关信号通路的信号转导途径,减少肾组织内TGF-β1的表达和炎症细胞的浸润、活化,从而改善肾组织的炎症性损伤.

关 键 词:黄葵胶囊  阿霉素肾病  炎症信号通路  p38MAPK  磷酸化p38MAPK
收稿时间:5/2/2012 12:00:00 AM

Effects of Huangkui capsule on renal inflammatory injury by intervening p38MAPK signaling pathway in rats with adriamycin-induced nephropathy
ZHAO Qing,WAN Yi-gang,SUN Wei,WANG Chao-jun,WEI Qing-xue,CHEN Hao-li and MENG Xian-jie.Effects of Huangkui capsule on renal inflammatory injury by intervening p38MAPK signaling pathway in rats with adriamycin-induced nephropathy[J].China Journal of Chinese Materia Medica,2012,37(19):2926-2934.
Authors:ZHAO Qing  WAN Yi-gang  SUN Wei  WANG Chao-jun  WEI Qing-xue  CHEN Hao-li and MENG Xian-jie
Institution:Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210008, China;Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China;Department of Nephrology, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing 210029, China;Kunshan Hospital of Traditional Chinese Medicine, Kunshan 215300, China;Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210008, China;Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210008, China;Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210008, China
Abstract:
Keywords:Huangkui capsule(HKC)  adriamycin-induced nephropathy  inflammation signaling pathway  p38 mitogen-activated protein kinase(MAPK)  phosphorylated p38MAPK(p-p38MAPK)
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