乌蔹莓化学成分的初步探究

目的:系统性研究福建道地药材乌蔹莓的有效成分.方法:运用大孔树脂,Sephadex LH-20,ODS及正相硅胶柱等色谱手段对乌蔹莓Cayratia japonica的全草进行分离.结果:从中得到13个化合物,通过多种波谱数据分析鉴定化合物结构,确定其分别为木犀草素(1),芹菜素(2),柠檬酸三乙酯(3),吲哚-3-甲醛(4),秦皮乙素(5),邻苯二甲酸二乙基己酯(6),calendin(7),反式咖啡酸乙酯(8),木犀草素7-O-葡萄糖苷(9),5-hydroxy-3,4-dimethyl-5-pentyl-2(5H)-furanone(10),3,4-二羟基苯甲酸乙酯(11),圣草酚(12),胡萝卜苷(13).结论:其中3～8及10～ 12均为首次从乌蔹莓中分离得到.

Preliminary study on chemical constituents seperated from Cayratia japonica

Objective: To study effective active constituents of Cayratia japonica,a genuine herbal medicine from Fujian. Method: Such chromatographic methods as Macroporous,Sephadex LH-20,ODS and normal phase silica gel column chromatography were adopted to separate the chemical components of C. japonica. Result: Thirteen compounds were obtained,and their structures were identified by analyzing multiple spectral data as luteolin(1),apigenin(2),triethyl citrate-(3),3-formylindole(4),esculetin(5),bis-(2-ethylhexyl)-phthalate(6),calendin(7),ethyl-trans-3,4-dihydr-oxycinnamate(8),luteolin7-O-D-glucoside(9),5-hydroxy-3,4-dimethyl-5-pentyl-2(5H)-furanone(10),ethyl-3,4-dihydroxybenzoate(11),eriodictyol(12) and daucosterol(13). Conclusion: Among them,compounds 3-8 and 10-12 were separated from the plant for the first time.