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| 国产沉香中的二萜类化学成分 | |
| 引用本文： | 杨林,乔立瑞,谢丹,戴均贵,郭顺星.国产沉香中的二萜类化学成分[J].中国中药杂志,2011,36(15):2088-2091. |
| 作者姓名： | 杨林 乔立瑞 谢丹 戴均贵 郭顺星 |
| 作者单位： | 1. 中国医学科学院北京协和医学院药用植物研究所,北京100193;中央民族大学生命与环境科学学院,北京100081 2. 中国医学科学院北京协和医学院药物研究所,北京,100050 3. 中国医学科学院北京协和医学院药用植物研究所,北京,100193 |
| 基金项目： | 国家"重大新药创制"科技重大专项(2009ZX09301-03-03);国际科技合作项目(2009DFA32250) |
| 摘 要： | 目的:研究国产沉香的化学成分.方法:通过多种色谱手段,对国产沉香的石油醚及乙醇提取物进行化学成分分离,采用现代波谱技术对化合物的结构进行鉴定.结果:从国产沉香中分离得到9个化合物,分别鉴定为去氢松香酸(1),去氢松香酸甲酯(2),methyl 7-oxodehydroabietate(3),7α,15-二羟基去氢松香酸(4),7αt-hydroxypodocarpen-8( 14) -en-13-on-18-oic acid(5),海松酸(6),海松醇(7),18 -norpimara-8 (14),15-dien-4α-ol(8),18-norisopimara-8( 14),15-dien-4β-ol(9).结论:化合物1～9均为首次从国产沉香中分离得到的二萜类化合物,其中化合物5,8,9为降二萜类化合物. |
| 关 键 词： | 国产沉香 二萜类 降二萜类 松香酸类 海松烷类 |
| 收稿时间： | 1/6/2011 12:00:00 AM |
Diterpenoids from Chinese Eaglewood |
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| YANG Lin,QIAO Lirui,XIE Dan,DAI Jungui and GUO Shunxing.Diterpenoids from Chinese Eaglewood[J].China Journal of Chinese Materia Medica,2011,36(15):2088-2091. | |
| Authors: | YANG Lin QIAO Lirui XIE Dan DAI Jungui and GUO Shunxing |
| Institution: | Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China;College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China;Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China;Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China;Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China;Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China |
| Abstract: | Column chromatography on silica gel, Sephadex LH-20, semi-preparative HPLC were used to separate and purify the compounds from the petroleum ether and ethanol extract of Chinese eaglewood. Nine compounds were isolated. On the basis of their spectroscopic data, their structures were identified as dehydroabietic acid (1), methyl dehydroabietate (2), methyl 7-oxodehydroabietate (3), 7alpha, 15-dihydroxydehydroabietic acid (4), 7alpha-hydroxypodocarpen-8(14)-en-13-on-18-oic acid (5), pimaric acid (6), pimarol (7), 18-norpimara-8 (14), and 15-dien-4alpha-ol (8), 18-norisopimara-8 (14), 15-dien-4beta-ol (9). All of the compounds were isolated from this plant for the first time, and compounds 5, 8 and 9 are norditerpenoids. |
| Keywords: | Chinese eaglewood diterpenoids norditerpenoids abietic acids pimaranes |
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