论自然环境因子变化对中药药性形成的影响

中药药性是中药理论的核心,是根据中医传统认识,与疗效有关的药物的性质或属性。药性功效的发挥是通过药材得以体现的,而药材的形成受到了外部环境的影响,包括药物生长的温度、湿度、降水、风、地形、土壤、微生物等因素。本文从中药药性形成的历代医籍考证入手,结合现代研究的认识和结果,剖析了中药生成禀受元素与自然环境因子之间的关系,探讨自然环境因子的变化对中药药性形成的影响,指出中药药性是中药秉承了自然环境中各元素的变化而形成的,是气候、土壤、生物、地形等各环境因子综合作用的结果。

Discuss on effect of physical environmental factors on natureof Chinese materia medica

Objective : To investigate the epileptic seizure-like effect of Sophora alkaloid sophoridine on electroencepholography (EEG) and its possible characteristic and the mechanism of the seizure-like effect. Method : Chronic electron implantation was employed for the intracranial electroencepholography (IEEG) recording in rat, and the traditional anti-seizure drugs were for the mechanism study in mice. Result : Compared with the medial perforant path (PP) area and the temporal cortex (TC) , the granule cells in hippocampus dentate gyrus (DG)area is more sensitive in the kindling effect by sc sophoridine. Under-threshold hypnotic dosage of diazepam and the hypnotic dosage of pentobarbital sodium can block the sophoridine kinded seizure in mice, but the phenytoin sodium can not block the seizure, also the dosage of it can block the maximal electroconvulsive shock (MES) seizure. Conclusion : Sophoridine-induced synchronous oscillations in the hippocampus could elicit the generation and development of seizure. And the hippocampus might play the crucial role and be the original part of the seizure.Sophoridine kinded seizure might belong to clonic seizures, and the diazepam is the ideal agent for the treatment.